Pterostilbene Prevents Early Diabetic Retinopathy Alterations in a Rabbit Experimental Model
Oxidative stress generated by diabetes plays a key role in the development of diabetic retinopathy (DR), a common diabetic complication. DR remains asymptomatic until it reaches advanced stages, which complicate its treatment. Although it is known that good metabolic control is essential for prevent...
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| Veröffentlicht in: | Nutrients 2019-12, Vol.12 (1), p.82 |
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| creator | Millán, Iván Desco, María Del Carmen Torres-Cuevas, Isabel Pérez, Salvador Pulido, Inés Mena-Mollá, Salvador Mataix, Jorge Asensi, Miguel Ortega, Ángel Luis |
| description | Oxidative stress generated by diabetes plays a key role in the development of diabetic retinopathy (DR), a common diabetic complication. DR remains asymptomatic until it reaches advanced stages, which complicate its treatment. Although it is known that good metabolic control is essential for preventing DR, knowledge of the disease is incomplete and an effective treatment with no side effects is lacking. Pterostilbene (Pter), a natural stilbene with good antioxidant activity, has proved to beneficially affect different pathologies, including diabetes. Therefore, our study aimed to analyse the protective and/or therapeutic capacity of Pter against oxidant damage by characterising early retinal alterations induced by hyperglycaemia, and its possible mechanism of action in a rabbit model of type 1 diabetes mellitus. Pter reduced lipid and protein oxidative damage, and recovered redox status and the main activities of antioxidant enzymes. Moreover, the redox regulation by Pter was associated with activation of the PI3K/AKT/GSK3β/NRF2 pathway. Our results show that Pter is a powerful protective agent that may delay early DR development. |
| doi_str_mv | 10.3390/nu12010082 |
| format | Article |
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DR remains asymptomatic until it reaches advanced stages, which complicate its treatment. Although it is known that good metabolic control is essential for preventing DR, knowledge of the disease is incomplete and an effective treatment with no side effects is lacking. Pterostilbene (Pter), a natural stilbene with good antioxidant activity, has proved to beneficially affect different pathologies, including diabetes. Therefore, our study aimed to analyse the protective and/or therapeutic capacity of Pter against oxidant damage by characterising early retinal alterations induced by hyperglycaemia, and its possible mechanism of action in a rabbit model of type 1 diabetes mellitus. Pter reduced lipid and protein oxidative damage, and recovered redox status and the main activities of antioxidant enzymes. Moreover, the redox regulation by Pter was associated with activation of the PI3K/AKT/GSK3β/NRF2 pathway. Our results show that Pter is a powerful protective agent that may delay early DR development.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12010082</identifier><identifier>PMID: 31892189</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Animal models ; Antioxidants ; Apoptosis ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetic retinopathy ; Disease control ; Edema ; Enzymes ; Ethanol ; Hyperglycemia ; Kinases ; Laboratory animals ; Lipids ; Medical treatment ; Oxidants ; Oxidative stress ; Oxidizing agents ; Polyphenols ; Proteins ; Retina ; Retinopathy ; Software ; Stilbene ; Vascular endothelial growth factor</subject><ispartof>Nutrients, 2019-12, Vol.12 (1), p.82</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-4ad2133f4b6b1cb9090b6e7aba9783cbb9f4985d6cd3f116940de3e6b27cf34a3</citedby><cites>FETCH-LOGICAL-c406t-4ad2133f4b6b1cb9090b6e7aba9783cbb9f4985d6cd3f116940de3e6b27cf34a3</cites><orcidid>0000-0003-0766-1744 ; 0000-0002-9901-3383 ; 0000-0002-9239-7847</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019414/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019414/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27906,27907,53773,53775</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31892189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Millán, Iván</creatorcontrib><creatorcontrib>Desco, María Del Carmen</creatorcontrib><creatorcontrib>Torres-Cuevas, Isabel</creatorcontrib><creatorcontrib>Pérez, Salvador</creatorcontrib><creatorcontrib>Pulido, Inés</creatorcontrib><creatorcontrib>Mena-Mollá, Salvador</creatorcontrib><creatorcontrib>Mataix, Jorge</creatorcontrib><creatorcontrib>Asensi, Miguel</creatorcontrib><creatorcontrib>Ortega, Ángel Luis</creatorcontrib><title>Pterostilbene Prevents Early Diabetic Retinopathy Alterations in a Rabbit Experimental Model</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Oxidative stress generated by diabetes plays a key role in the development of diabetic retinopathy (DR), a common diabetic complication. DR remains asymptomatic until it reaches advanced stages, which complicate its treatment. Although it is known that good metabolic control is essential for preventing DR, knowledge of the disease is incomplete and an effective treatment with no side effects is lacking. Pterostilbene (Pter), a natural stilbene with good antioxidant activity, has proved to beneficially affect different pathologies, including diabetes. Therefore, our study aimed to analyse the protective and/or therapeutic capacity of Pter against oxidant damage by characterising early retinal alterations induced by hyperglycaemia, and its possible mechanism of action in a rabbit model of type 1 diabetes mellitus. Pter reduced lipid and protein oxidative damage, and recovered redox status and the main activities of antioxidant enzymes. Moreover, the redox regulation by Pter was associated with activation of the PI3K/AKT/GSK3β/NRF2 pathway. Our results show that Pter is a powerful protective agent that may delay early DR development.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Animal models</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetic retinopathy</subject><subject>Disease control</subject><subject>Edema</subject><subject>Enzymes</subject><subject>Ethanol</subject><subject>Hyperglycemia</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Lipids</subject><subject>Medical treatment</subject><subject>Oxidants</subject><subject>Oxidative stress</subject><subject>Oxidizing agents</subject><subject>Polyphenols</subject><subject>Proteins</subject><subject>Retina</subject><subject>Retinopathy</subject><subject>Software</subject><subject>Stilbene</subject><subject>Vascular endothelial growth factor</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkeFLXSEYxmVsrGh96Q8IoS8juE2PTo9fgrjdbUGxiO1bIOp5TxlevVNPdP_7eVdrLeHVF_y9D48-CO1RcsSYIp_iRDtCCem7N2i7I7KbCcHZ2xf9Ftot5Y5sliRSsPdoi9Feda220fVlhZxK9cFCBHyZ4R5iLXhhcljjU28sVO_wVdtjWpl6u8YnoY2Y6lMs2Eds8JWx1le8eFhB9ss2bgK-SAOED-jdaEKB3adzB_38svgx_zY7__71bH5yPnOciDrjZugoYyO3wlJnFVHECpDGGiV75qxVI1f950G4gY2UCsXJAAyE7aQbGTdsBx0_6q4mu4TBNQvZBL1qbkxe62S8_v8m-lt9k-61JFRxypvAxyeBnH5NUKpe-uIgBBMhTUV3jFGpFJUb9OAVepemHNvzNhTpmZR_qMNHyrXPLRnGZzOU6E1u-l9uDd5_af8Z_ZsS-w2eOZQl</recordid><startdate>20191227</startdate><enddate>20191227</enddate><creator>Millán, Iván</creator><creator>Desco, María Del Carmen</creator><creator>Torres-Cuevas, Isabel</creator><creator>Pérez, Salvador</creator><creator>Pulido, Inés</creator><creator>Mena-Mollá, Salvador</creator><creator>Mataix, Jorge</creator><creator>Asensi, Miguel</creator><creator>Ortega, Ángel Luis</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0766-1744</orcidid><orcidid>https://orcid.org/0000-0002-9901-3383</orcidid><orcidid>https://orcid.org/0000-0002-9239-7847</orcidid></search><sort><creationdate>20191227</creationdate><title>Pterostilbene Prevents Early Diabetic Retinopathy Alterations in a Rabbit Experimental Model</title><author>Millán, Iván ; 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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Animal models Antioxidants Apoptosis Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetic retinopathy Disease control Edema Enzymes Ethanol Hyperglycemia Kinases Laboratory animals Lipids Medical treatment Oxidants Oxidative stress Oxidizing agents Polyphenols Proteins Retina Retinopathy Software Stilbene Vascular endothelial growth factor |
| title | Pterostilbene Prevents Early Diabetic Retinopathy Alterations in a Rabbit Experimental Model |
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