Probiotics Used for Postoperative Infections in Patients Undergoing Colorectal Cancer Surgery
Objective. The objective of this study was to conduct a systematic review and meta-analysis about probiotics to improve postoperative infections in patients undergoing colorectal cancer surgery. Methods. The PubMed and the Web of Science were used to search for appropriate randomized clinical trials...
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| description | Objective. The objective of this study was to conduct a systematic review and meta-analysis about probiotics to improve postoperative infections in patients undergoing colorectal cancer surgery. Methods. The PubMed and the Web of Science were used to search for appropriate randomized clinical trials (RCTs) comparing probiotics with placebo for the patients undergoing colorectal cancer surgery. The RevMan 5.3 was performed for meta-analysis to evaluate the postoperative infection, including the total infection, surgical site infection, central line infection, pneumonia, urinary tract infection, septicemia, and postoperative leakage. Results. Our meta-analysis included 6 studies involving a total of 803 patients. For the incidence of total postoperative infection (odd ratios (OR) 0.31, 95% confidence interval (CI) 0.15–0.64, I 2 =0%), surgical site infection (OR 0.62, 95% CI 0.39–0.99, I 2 =11%), central line infection (OR 0.61, 95% CI 0.15–2.45, I 2 =65%), pneumonia (OR 0.36, 95% CI 0.18–0.71, I 2 =0%), urinary tract infection (OR 0.26, 95% CI 0.11–0.60, I 2 =26%), septicemia (OR 0.28, 95% CI 0.17–0.49, I 2 =10%), postoperative leakage (OR 0.45, 95% CI 0.06–3.27, I 2 =68%), the results showed that the incidences of infections were significantly lower in the probiotics group than the placebo group. Conclusions. Probiotics is beneficial to prevent postoperative infections (including total postoperative infection, surgical site infection, pneumonia, urinary tract infection, and septicemia) in patients with colorectal cancer. |
| doi_str_mv | 10.1155/2020/5734718 |
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The objective of this study was to conduct a systematic review and meta-analysis about probiotics to improve postoperative infections in patients undergoing colorectal cancer surgery. Methods. The PubMed and the Web of Science were used to search for appropriate randomized clinical trials (RCTs) comparing probiotics with placebo for the patients undergoing colorectal cancer surgery. The RevMan 5.3 was performed for meta-analysis to evaluate the postoperative infection, including the total infection, surgical site infection, central line infection, pneumonia, urinary tract infection, septicemia, and postoperative leakage. Results. Our meta-analysis included 6 studies involving a total of 803 patients. For the incidence of total postoperative infection (odd ratios (OR) 0.31, 95% confidence interval (CI) 0.15–0.64, I 2 =0%), surgical site infection (OR 0.62, 95% CI 0.39–0.99, I 2 =11%), central line infection (OR 0.61, 95% CI 0.15–2.45, I 2 =65%), pneumonia (OR 0.36, 95% CI 0.18–0.71, I 2 =0%), urinary tract infection (OR 0.26, 95% CI 0.11–0.60, I 2 =26%), septicemia (OR 0.28, 95% CI 0.17–0.49, I 2 =10%), postoperative leakage (OR 0.45, 95% CI 0.06–3.27, I 2 =68%), the results showed that the incidences of infections were significantly lower in the probiotics group than the placebo group. Conclusions. Probiotics is beneficial to prevent postoperative infections (including total postoperative infection, surgical site infection, pneumonia, urinary tract infection, and septicemia) in patients with colorectal cancer.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2020/5734718</identifier><identifier>PMID: 32076609</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analysis ; Bacteria ; Bacterial pneumonia ; Bias ; Biomedical research ; Biotechnology & Applied Microbiology ; Cancer ; Cancer patients ; Cancer surgery ; Clinical trials ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - surgery ; Confidence intervals ; Databases, Factual ; Digestive System Surgical Procedures - adverse effects ; Handbooks ; Health aspects ; Humans ; Leakage ; Life Sciences & Biomedicine ; Medical research ; Medicine, Experimental ; Medicine, Research & Experimental ; Meta-analysis ; Patients ; Pneumonia ; Pneumonia - therapy ; Postoperative infection ; Prevention ; Probiotics ; Probiotics - therapeutic use ; Research & Experimental Medicine ; Review ; Science & Technology ; Sepsis ; Sepsis - therapy ; Septicemia ; Studies ; Surgery ; Surgical site infections ; Surgical Wound Infection - therapy ; Urinary tract ; Urinary tract diseases ; Urinary tract infections ; Urinary Tract Infections - therapy ; Urogenital system</subject><ispartof>BioMed research international, 2020, Vol.2020 (2020), p.1-8, Article 5734718</ispartof><rights>Copyright © 2020 Chongxiang Chen et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Chongxiang Chen et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Chongxiang Chen et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>18</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000514386900013</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c499t-4a0138d5e4082b59b11068d83698d4dbade84cc21162f1a41c910804a91ab76f3</citedby><cites>FETCH-LOGICAL-c499t-4a0138d5e4082b59b11068d83698d4dbade84cc21162f1a41c910804a91ab76f3</cites><orcidid>0000-0002-9694-6022 ; 0000-0002-7238-1987</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019203/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019203/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,4026,27930,27931,27932,28255,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32076609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Liu, Yatao</contributor><contributor>Yatao Liu</contributor><creatorcontrib>Chen, Chongxiang</creatorcontrib><creatorcontrib>Zhao, Qingyu</creatorcontrib><creatorcontrib>Wen, Tianmeng</creatorcontrib><title>Probiotics Used for Postoperative Infections in Patients Undergoing Colorectal Cancer Surgery</title><title>BioMed research international</title><addtitle>BIOMED RES INT</addtitle><addtitle>Biomed Res Int</addtitle><description>Objective. The objective of this study was to conduct a systematic review and meta-analysis about probiotics to improve postoperative infections in patients undergoing colorectal cancer surgery. Methods. The PubMed and the Web of Science were used to search for appropriate randomized clinical trials (RCTs) comparing probiotics with placebo for the patients undergoing colorectal cancer surgery. The RevMan 5.3 was performed for meta-analysis to evaluate the postoperative infection, including the total infection, surgical site infection, central line infection, pneumonia, urinary tract infection, septicemia, and postoperative leakage. Results. Our meta-analysis included 6 studies involving a total of 803 patients. For the incidence of total postoperative infection (odd ratios (OR) 0.31, 95% confidence interval (CI) 0.15–0.64, I 2 =0%), surgical site infection (OR 0.62, 95% CI 0.39–0.99, I 2 =11%), central line infection (OR 0.61, 95% CI 0.15–2.45, I 2 =65%), pneumonia (OR 0.36, 95% CI 0.18–0.71, I 2 =0%), urinary tract infection (OR 0.26, 95% CI 0.11–0.60, I 2 =26%), septicemia (OR 0.28, 95% CI 0.17–0.49, I 2 =10%), postoperative leakage (OR 0.45, 95% CI 0.06–3.27, I 2 =68%), the results showed that the incidences of infections were significantly lower in the probiotics group than the placebo group. Conclusions. Probiotics is beneficial to prevent postoperative infections (including total postoperative infection, surgical site infection, pneumonia, urinary tract infection, and septicemia) in patients with colorectal cancer.</description><subject>Analysis</subject><subject>Bacteria</subject><subject>Bacterial pneumonia</subject><subject>Bias</subject><subject>Biomedical research</subject><subject>Biotechnology & Applied Microbiology</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer surgery</subject><subject>Clinical trials</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Confidence intervals</subject><subject>Databases, Factual</subject><subject>Digestive System Surgical Procedures - adverse effects</subject><subject>Handbooks</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Leakage</subject><subject>Life Sciences & Biomedicine</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Medicine, Research & Experimental</subject><subject>Meta-analysis</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Pneumonia - therapy</subject><subject>Postoperative infection</subject><subject>Prevention</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Research & Experimental Medicine</subject><subject>Review</subject><subject>Science & Technology</subject><subject>Sepsis</subject><subject>Sepsis - therapy</subject><subject>Septicemia</subject><subject>Studies</subject><subject>Surgery</subject><subject>Surgical site infections</subject><subject>Surgical Wound Infection - therapy</subject><subject>Urinary tract</subject><subject>Urinary tract diseases</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - therapy</subject><subject>Urogenital system</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0kFr2zAUB3AzNtbS9bbzMOwy6LLqSbIsXQbFbGuhsMDW4xCy_JyqOFIm2S399pNJlqw71Rc9rJ-en_i7KN4C-QRQVeeUUHJe1YzXIF8Ux5QBXwjg8HJfM3ZUnKZ0R_IjQRAlXhdHjJJa5Pq4-LWMoXVhdDaVNwm7sg-xXIY0hg1GM7p7LK98j3Z0wafS-XKZX6Ifs_YdxlVwflU2YQgxGzOUjfEWY_ljiiuMj2-KV70ZEp7u1pPi5uuXn83l4vr7t6vm4nphuVLjghsCTHYVciJpW6kWgAjZSSaU7HjXmg4lt5YCCNqD4WAVEEm4UWDaWvTspPi87buZ2jV2Ng8YzaA30a1NfNTBOP10x7tbvQr3uiagKGG5wYddgxh-T5hGvXbJ4jAYj2FKmrJKcUI4rTJ9_x-9C1P0-XqzooIQKulBrcyA2vk-5O_auam-EJSyuiIUsvq4VTaGlCL2-5GB6DlgPQesdwFn_u7fa-7x3zgzkFvwgG3ok81JWdyz_AdUwJkUKlfAGjeaOdYmTH7MR8-ef_Sgb53vzIN75tyYDfbmoIFxqRT7A-fG1qI</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Chen, Chongxiang</creator><creator>Zhao, Qingyu</creator><creator>Wen, Tianmeng</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Publishing Group</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9694-6022</orcidid><orcidid>https://orcid.org/0000-0002-7238-1987</orcidid></search><sort><creationdate>2020</creationdate><title>Probiotics Used for Postoperative Infections in Patients Undergoing Colorectal Cancer Surgery</title><author>Chen, Chongxiang ; Zhao, Qingyu ; Wen, Tianmeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-4a0138d5e4082b59b11068d83698d4dbade84cc21162f1a41c910804a91ab76f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Bacteria</topic><topic>Bacterial pneumonia</topic><topic>Bias</topic><topic>Biomedical research</topic><topic>Biotechnology & Applied Microbiology</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer surgery</topic><topic>Clinical trials</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Confidence intervals</topic><topic>Databases, Factual</topic><topic>Digestive System Surgical Procedures - adverse effects</topic><topic>Handbooks</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Leakage</topic><topic>Life Sciences & Biomedicine</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Medicine, Research & Experimental</topic><topic>Meta-analysis</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Pneumonia - therapy</topic><topic>Postoperative infection</topic><topic>Prevention</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Research & Experimental Medicine</topic><topic>Review</topic><topic>Science & Technology</topic><topic>Sepsis</topic><topic>Sepsis - therapy</topic><topic>Septicemia</topic><topic>Studies</topic><topic>Surgery</topic><topic>Surgical site infections</topic><topic>Surgical Wound Infection - therapy</topic><topic>Urinary tract</topic><topic>Urinary tract diseases</topic><topic>Urinary tract infections</topic><topic>Urinary Tract Infections - therapy</topic><topic>Urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chongxiang</creatorcontrib><creatorcontrib>Zhao, Qingyu</creatorcontrib><creatorcontrib>Wen, Tianmeng</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chongxiang</au><au>Zhao, Qingyu</au><au>Wen, Tianmeng</au><au>Liu, Yatao</au><au>Yatao Liu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotics Used for Postoperative Infections in Patients Undergoing Colorectal Cancer Surgery</atitle><jtitle>BioMed research international</jtitle><stitle>BIOMED RES INT</stitle><addtitle>Biomed Res Int</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><artnum>5734718</artnum><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Objective. The objective of this study was to conduct a systematic review and meta-analysis about probiotics to improve postoperative infections in patients undergoing colorectal cancer surgery. Methods. The PubMed and the Web of Science were used to search for appropriate randomized clinical trials (RCTs) comparing probiotics with placebo for the patients undergoing colorectal cancer surgery. The RevMan 5.3 was performed for meta-analysis to evaluate the postoperative infection, including the total infection, surgical site infection, central line infection, pneumonia, urinary tract infection, septicemia, and postoperative leakage. Results. Our meta-analysis included 6 studies involving a total of 803 patients. For the incidence of total postoperative infection (odd ratios (OR) 0.31, 95% confidence interval (CI) 0.15–0.64, I 2 =0%), surgical site infection (OR 0.62, 95% CI 0.39–0.99, I 2 =11%), central line infection (OR 0.61, 95% CI 0.15–2.45, I 2 =65%), pneumonia (OR 0.36, 95% CI 0.18–0.71, I 2 =0%), urinary tract infection (OR 0.26, 95% CI 0.11–0.60, I 2 =26%), septicemia (OR 0.28, 95% CI 0.17–0.49, I 2 =10%), postoperative leakage (OR 0.45, 95% CI 0.06–3.27, I 2 =68%), the results showed that the incidences of infections were significantly lower in the probiotics group than the placebo group. Conclusions. Probiotics is beneficial to prevent postoperative infections (including total postoperative infection, surgical site infection, pneumonia, urinary tract infection, and septicemia) in patients with colorectal cancer.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32076609</pmid><doi>10.1155/2020/5734718</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9694-6022</orcidid><orcidid>https://orcid.org/0000-0002-7238-1987</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Bacteria Bacterial pneumonia Bias Biomedical research Biotechnology & Applied Microbiology Cancer Cancer patients Cancer surgery Clinical trials Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - surgery Confidence intervals Databases, Factual Digestive System Surgical Procedures - adverse effects Handbooks Health aspects Humans Leakage Life Sciences & Biomedicine Medical research Medicine, Experimental Medicine, Research & Experimental Meta-analysis Patients Pneumonia Pneumonia - therapy Postoperative infection Prevention Probiotics Probiotics - therapeutic use Research & Experimental Medicine Review Science & Technology Sepsis Sepsis - therapy Septicemia Studies Surgery Surgical site infections Surgical Wound Infection - therapy Urinary tract Urinary tract diseases Urinary tract infections Urinary Tract Infections - therapy Urogenital system |
| title | Probiotics Used for Postoperative Infections in Patients Undergoing Colorectal Cancer Surgery |
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