Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia
A diagnosis of schizophrenia is associated with a heterogeneous psychopathology including positive and negative symptoms. The disconnection hypothesis, an early pathophysiological framework conceptualizes the diversity of symptoms as a result of disconnections in neural networks. In line with this h...
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| Veröffentlicht in: | Scientific reports 2020-02, Vol.10 (1), p.2616-2616, Article 2616 |
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| creator | Forlim, Caroline Garcia Klock, Leonie Bächle, Johanna Stoll, Laura Giemsa, Patrick Fuchs, Marie Schoofs, Nikola Montag, Christiane Gallinat, Jürgen Kühn, Simone |
| description | A diagnosis of schizophrenia is associated with a heterogeneous psychopathology including positive and negative symptoms. The disconnection hypothesis, an early pathophysiological framework conceptualizes the diversity of symptoms as a result of disconnections in neural networks. In line with this hypothesis, previous neuroimaging studies of patients with schizophrenia reported alterations within the default mode network (DMN), the most prominent network at rest. The aim of the present study was to investigate the functional connectivity during rest in patients with schizophrenia and with healthy individuals and explore whether observed functional alterations are related to the psychopathology of patients. Therefore, functional magnetic resonance images at rest were recorded of 35 patients with schizophrenia and 41 healthy individuals. Independent component analysis (ICA) was used to extract resting state networks. Comparing ICA results between groups indicated alterations only within the network of the DMN. More explicitly, reduced connectivity in the precuneus was observed in patients with schizophrenia compared to healthy controls. Connectivity in this area was negatively correlated with the severity of negative symptoms, more specifically with the domain of apathy. Taken together, the current results provide further evidence for a role DMN alterations might play in schizophrenia and especially in negative symptoms such as apathy. |
| doi_str_mv | 10.1038/s41598-020-59393-6 |
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The disconnection hypothesis, an early pathophysiological framework conceptualizes the diversity of symptoms as a result of disconnections in neural networks. In line with this hypothesis, previous neuroimaging studies of patients with schizophrenia reported alterations within the default mode network (DMN), the most prominent network at rest. The aim of the present study was to investigate the functional connectivity during rest in patients with schizophrenia and with healthy individuals and explore whether observed functional alterations are related to the psychopathology of patients. Therefore, functional magnetic resonance images at rest were recorded of 35 patients with schizophrenia and 41 healthy individuals. Independent component analysis (ICA) was used to extract resting state networks. Comparing ICA results between groups indicated alterations only within the network of the DMN. More explicitly, reduced connectivity in the precuneus was observed in patients with schizophrenia compared to healthy controls. Connectivity in this area was negatively correlated with the severity of negative symptoms, more specifically with the domain of apathy. Taken together, the current results provide further evidence for a role DMN alterations might play in schizophrenia and especially in negative symptoms such as apathy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-59393-6</identifier><identifier>PMID: 32054907</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/36 ; 631/378 ; 692/699/476/1799 ; Adult ; Apathy ; Connectome ; Cortex (parietal) ; Emotional behavior ; Female ; Humanities and Social Sciences ; Humans ; Hypotheses ; Magnetic Resonance Imaging ; Male ; Mental disorders ; Middle Aged ; multidisciplinary ; Nerve Net - physiopathology ; Neural networks ; Neuroimaging ; Parietal Lobe - physiopathology ; Psychopathology ; Rest ; Schizophrenia ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Science ; Science (multidisciplinary) ; Young Adult</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.2616-2616, Article 2616</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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The disconnection hypothesis, an early pathophysiological framework conceptualizes the diversity of symptoms as a result of disconnections in neural networks. In line with this hypothesis, previous neuroimaging studies of patients with schizophrenia reported alterations within the default mode network (DMN), the most prominent network at rest. The aim of the present study was to investigate the functional connectivity during rest in patients with schizophrenia and with healthy individuals and explore whether observed functional alterations are related to the psychopathology of patients. Therefore, functional magnetic resonance images at rest were recorded of 35 patients with schizophrenia and 41 healthy individuals. Independent component analysis (ICA) was used to extract resting state networks. Comparing ICA results between groups indicated alterations only within the network of the DMN. More explicitly, reduced connectivity in the precuneus was observed in patients with schizophrenia compared to healthy controls. Connectivity in this area was negatively correlated with the severity of negative symptoms, more specifically with the domain of apathy. Taken together, the current results provide further evidence for a role DMN alterations might play in schizophrenia and especially in negative symptoms such as apathy.</description><subject>59/36</subject><subject>631/378</subject><subject>692/699/476/1799</subject><subject>Adult</subject><subject>Apathy</subject><subject>Connectome</subject><subject>Cortex (parietal)</subject><subject>Emotional behavior</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Nerve Net - physiopathology</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Parietal Lobe - physiopathology</subject><subject>Psychopathology</subject><subject>Rest</subject><subject>Schizophrenia</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctu1DAUhi1ERau2L8ACWWLDJuDrON4gVaNykSpRtbC2HOfMxFXGHmynqDw9TlNKYYE3tny-85_Lj9BLSt5Swtt3WVCp24Yw0kjNNW9Wz9ARI0I2jDP2_Mn7EJ3mfEPqkUwLql-gQ86IFJqoIzReQT856PEV5OLDtrkutgBexxDAFX_ryx32AZcB8GUCNwWYMvYZu5gSjBXt8Q9fBny2t2W4Ry9t8RBKXv6v3eB_xv2QIHh7gg42dsxw-nAfo28fzr-uPzUXXz5-Xp9dNE4yVhplhe4p5VoIazvFmJZE9FQR6zbctkp1YsXbtgWioKcr0vUgOyZtS0hnda_4MXq_6O6nbge9q-0kO5p98jub7ky03vwdCX4w23hrFKGtVqIKvHkQSPH7VDdjdj47GEcbIE7ZMC7npUsxo6__QW_ilEIdb6aEooK0c0dsoVyKOSfYPDZDiZn9NIufpvpp7v00q5r06ukYjym_3asAX4BcQ2EL6U_t_8j-AtIorIs</recordid><startdate>20200213</startdate><enddate>20200213</enddate><creator>Forlim, Caroline Garcia</creator><creator>Klock, Leonie</creator><creator>Bächle, Johanna</creator><creator>Stoll, Laura</creator><creator>Giemsa, Patrick</creator><creator>Fuchs, Marie</creator><creator>Schoofs, Nikola</creator><creator>Montag, Christiane</creator><creator>Gallinat, Jürgen</creator><creator>Kühn, Simone</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200213</creationdate><title>Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia</title><author>Forlim, Caroline Garcia ; Klock, Leonie ; Bächle, Johanna ; Stoll, Laura ; Giemsa, Patrick ; Fuchs, Marie ; Schoofs, Nikola ; Montag, Christiane ; Gallinat, Jürgen ; Kühn, Simone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-7a49d113944aab7229504d170acf3a877b463888e07ed160bde5b25a800ba9d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>59/36</topic><topic>631/378</topic><topic>692/699/476/1799</topic><topic>Adult</topic><topic>Apathy</topic><topic>Connectome</topic><topic>Cortex (parietal)</topic><topic>Emotional behavior</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Nerve Net - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forlim, Caroline Garcia</au><au>Klock, Leonie</au><au>Bächle, Johanna</au><au>Stoll, Laura</au><au>Giemsa, Patrick</au><au>Fuchs, Marie</au><au>Schoofs, Nikola</au><au>Montag, Christiane</au><au>Gallinat, Jürgen</au><au>Kühn, Simone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-02-13</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>2616</spage><epage>2616</epage><pages>2616-2616</pages><artnum>2616</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>A diagnosis of schizophrenia is associated with a heterogeneous psychopathology including positive and negative symptoms. The disconnection hypothesis, an early pathophysiological framework conceptualizes the diversity of symptoms as a result of disconnections in neural networks. In line with this hypothesis, previous neuroimaging studies of patients with schizophrenia reported alterations within the default mode network (DMN), the most prominent network at rest. The aim of the present study was to investigate the functional connectivity during rest in patients with schizophrenia and with healthy individuals and explore whether observed functional alterations are related to the psychopathology of patients. Therefore, functional magnetic resonance images at rest were recorded of 35 patients with schizophrenia and 41 healthy individuals. Independent component analysis (ICA) was used to extract resting state networks. Comparing ICA results between groups indicated alterations only within the network of the DMN. 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| subjects | 59/36 631/378 692/699/476/1799 Adult Apathy Connectome Cortex (parietal) Emotional behavior Female Humanities and Social Sciences Humans Hypotheses Magnetic Resonance Imaging Male Mental disorders Middle Aged multidisciplinary Nerve Net - physiopathology Neural networks Neuroimaging Parietal Lobe - physiopathology Psychopathology Rest Schizophrenia Schizophrenia - physiopathology Schizophrenic Psychology Science Science (multidisciplinary) Young Adult |
| title | Reduced Resting-State Connectivity in the Precuneus is correlated with Apathy in Patients with Schizophrenia |
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