Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease

There is a need for continued drug development for nonalcoholic steatohepatitis (NASH). Bergamot is a plant whose fruit juice is enriched with flavonoids and phenolic compounds which improves dyslipidemia and markers of systemic inflammation in patients with Metabolic Syndrome. The aim of this study...

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Veröffentlicht in:	Scientific reports 2020-02, Vol.10 (1), p.2565, Article 2565
Hauptverfasser:	Musolino, Vincenzo, Gliozzi, Micaela, Scarano, Federica, Bosco, Francesca, Scicchitano, Miriam, Nucera, Saverio, Carresi, Cristina, Ruga, Stefano, Zito, Maria Caterina, Maiuolo, Jessica, Macrì, Roberta, Amodio, Nicola, Juli, Giada, Tassone, Pierfrancesco, Mollace, Rocco, Caffrey, Rebecca, Marioneaux, Jonathon, Walker, Ross, Ehrlich, James, Palma, Ernesto, Muscoli, Carolina, Bedossa, Pierre, Salvemini, Daniela, Mollace, Vincenzo, Sanyal, Arun J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/2 13/51 14 14/63 38 42 45 59 631/154/555 631/1647/334/1874/345 64/60 692/163/2743/2037 692/4020/4021/1607/2750 692/4020/4021/1607/2751 82 82/29 82/80 Animal models Animals Body weight Citrus - chemistry Collagen Collagen (type I) Diet Diet, Western - adverse effects Disease Models, Animal Drinking behavior Drinking water Drug development Dyslipidemia Dyslipidemias - drug therapy Dyslipidemias - genetics Dyslipidemias - pathology Fatty liver Fibrosis Flavonoids Fruit juices Gene Expression - drug effects High fat diet Humanities and Social Sciences Humans Inflammation - drug therapy Inflammation - genetics Inflammation - pathology Kinases Liver diseases Low density lipoprotein MAP kinase MAP Kinase Kinase 4 - genetics Metabolic disorders Metabolic syndrome Mice multidisciplinary Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - pathology Oxidative stress Oxidative Stress - drug effects p38 Mitogen-Activated Protein Kinases - genetics Phenolic compounds Phenols Polyphenols Polyphenols - chemistry Procollagen Science Science (multidisciplinary) Triglycerides
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