The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis

Gastric cancer (GC) is characterized by extensive local invasion, distant metastasis and poor prognosis. In most cases, GC progression is associated with aberrant expression of cytokines or activation of signaling cascades mediated by tumor–stroma interactions. However, the mechanisms by which these...

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Veröffentlicht in:	Oncogene 2020-02, Vol.39 (7), p.1414-1428
Hauptverfasser:	Zhou, Quan, Wu, Xiongyan, Wang, Xiaofeng, Yu, Zhenjia, Pan, Tao, Li, Zhen, Chang, Xinyu, Jin, Zhijian, Li, Jianfang, Zhu, Zhenggang, Liu, Bingya, Su, Liping
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/105 13/106 13/51 13/95 38/89 38/90 42/109 631/67/1504/1829 631/67/327 631/80/304 Apoptosis Cancer-Associated Fibroblasts - pathology Cell Biology Cell Communication Cell culture Cell Movement Cytokines Epithelial-Mesenchymal Transition Female Fibroblasts Gastric cancer Gene Expression Regulation, Neoplastic Human Genetics Humans Inflammation Interferon regulatory factor 1 Interleukin-1 Receptor-Like 1 Protein - metabolism Interleukin-33 - metabolism Internal Medicine Male Medical prognosis Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Middle Aged Neoplasm Invasiveness Neoplasm Metastasis NF-κB protein Oncology Peritoneum Prognosis Signal Transduction Stomach Neoplasms - diagnosis Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stroma Tumor cells Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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