Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts

Background Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the severity and progression of Parkinson's disease, however, has not been well s...

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Veröffentlicht in:	Movement disorders 2019-12, Vol.34 (12), p.1839-1850
Hauptverfasser:	Iwaki, Hirotaka, Blauwendraat, Cornelis, Leonard, Hampton L., Kim, Jonggeol J., Liu, Ganqiang, Maple‐Grødem, Jodi, Corvol, Jean‐Christophe, Pihlstrøm, Lasse, Nimwegen, Marlies, Hutten, Samantha J., Nguyen, Khanh‐Dung H., Rick, Jacqueline, Eberly, Shirley, Faghri, Faraz, Auinger, Peggy, Scott, Kirsten M., Wijeyekoon, Ruwani, Van Deerlin, Vivianna M., Hernandez, Dena G., Gibbs, J. Raphael, Chitrala, Kumaraswamy Naidu, Day‐Williams, Aaron G., Brice, Alexis, Alves, Guido, Noyce, Alastair J., Tysnes, Ole‐Bjørn, Evans, Jonathan R., Breen, David P., Estrada, Karol, Wegel, Claire E., Danjou, Fabrice, Simon, David K., Andreassen, Ole, Ravina, Bernard, Toft, Mathias, Heutink, Peter, Bloem, Bastiaan R., Weintraub, Daniel, Barker, Roger A., Williams‐Gray, Caroline H., Warrenburg, Bart P., Van Hilten, Jacobus J., Scherzer, Clemens R., Singleton, Andrew B., Nalls, Mike A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Adult Aged Aged, 80 and over Antigens, CD - genetics Apolipoprotein E Apolipoprotein E4 Biomarkers Cognitive ability Cognitive Dysfunction - etiology Cognitive Dysfunction - genetics Cognitive Dysfunction - psychology Cohort Studies Cross-Sectional Studies Disease Progression Female GBA Genetic diversity Genetic factors Genome-Wide Association Study genomewide association study Glucosylceramidase - genetics Human health and pathology Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics Life Sciences Longitudinal Studies LRRK2 protein Male Middle Aged Movement disorders Neurodegenerative diseases Organic Cation Transport Proteins - genetics Parkinson Disease - genetics Parkinson Disease - psychology Parkinson's disease Phenotype Phenotypes Quantitative trait loci Risk Assessment Sleep disorders
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