Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective
Cytoskeletal proteins, which consist of different sub-families of proteins including microtubules, actin and intermediate filaments, are essential for survival and cellular processes in both normal as well as cancer cells. However, in cancer cells, these mechanisms can be altered to promote tumour d...
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| Veröffentlicht in: | Cancers 2020-01, Vol.12 (1), p.238 |
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| creator | Ong, Mei Shan Deng, Shuo Halim, Clarissa Esmeralda Cai, Wanpei Tan, Tuan Zea Huang, Ruby Yun-Ju Sethi, Gautam Hooi, Shing Chuan Kumar, Alan Prem Yap, Celestial T |
| description | Cytoskeletal proteins, which consist of different sub-families of proteins including microtubules, actin and intermediate filaments, are essential for survival and cellular processes in both normal as well as cancer cells. However, in cancer cells, these mechanisms can be altered to promote tumour development and progression, whereby the functions of cytoskeletal proteins are co-opted to facilitate increased migrative and invasive capabilities, proliferation, as well as resistance to cellular and environmental stresses. Herein, we discuss the cytoskeletal responses to important intracellular stresses (such as mitochondrial, endoplasmic reticulum and oxidative stresses), and delineate the consequences of these responses, including effects on oncogenic signalling. In addition, we elaborate how the cytoskeleton and its associated molecules present themselves as therapeutic targets. The potential and limitations of targeting new classes of cytoskeletal proteins are also explored, in the context of developing novel strategies that impact cancer progression. |
| doi_str_mv | 10.3390/cancers12010238 |
| format | Article |
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However, in cancer cells, these mechanisms can be altered to promote tumour development and progression, whereby the functions of cytoskeletal proteins are co-opted to facilitate increased migrative and invasive capabilities, proliferation, as well as resistance to cellular and environmental stresses. Herein, we discuss the cytoskeletal responses to important intracellular stresses (such as mitochondrial, endoplasmic reticulum and oxidative stresses), and delineate the consequences of these responses, including effects on oncogenic signalling. In addition, we elaborate how the cytoskeleton and its associated molecules present themselves as therapeutic targets. The potential and limitations of targeting new classes of cytoskeletal proteins are also explored, in the context of developing novel strategies that impact cancer progression.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers12010238</identifier><identifier>PMID: 31963677</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Actin ; Apoptosis ; Cancer ; Cancer therapies ; Cell adhesion & migration ; Cell division ; Cytokeratin ; Cytoskeleton ; Endoplasmic reticulum ; Filaments ; Intermediate filaments ; Intracellular ; Invasiveness ; Kinases ; Medical prognosis ; Melanoma ; Metastasis ; Microtubules ; Mitochondria ; Morphology ; Motility ; Mutation ; Oxidative stress ; Prostate ; Proteins ; Review ; Tumorigenesis ; Tumors</subject><ispartof>Cancers, 2020-01, Vol.12 (1), p.238</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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The potential and limitations of targeting new classes of cytoskeletal proteins are also explored, in the context of developing novel strategies that impact cancer progression.</description><subject>Actin</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell adhesion & migration</subject><subject>Cell division</subject><subject>Cytokeratin</subject><subject>Cytoskeleton</subject><subject>Endoplasmic reticulum</subject><subject>Filaments</subject><subject>Intermediate filaments</subject><subject>Intracellular</subject><subject>Invasiveness</subject><subject>Kinases</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>Microtubules</subject><subject>Mitochondria</subject><subject>Morphology</subject><subject>Motility</subject><subject>Mutation</subject><subject>Oxidative stress</subject><subject>Prostate</subject><subject>Proteins</subject><subject>Review</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc9rwjAcxcPYmOI87zYCu-ziTJo2aXcYDNkPQZigO4c0_XbW1bZLUsH_fnE6cebyDcnn-3iPh9A1JfeMJWSoVaXBWBoQSgIWn6FuQEQw4DwJz4_uHdS3dkn8YYwKLi5Rh9GEMy5EF81GG1fbLyjBqRJPTe2gqCwuKjz6VceqyvC4ckZpKMu2VAbPnAFrH_ATni_AqAZaV2g89U4a0K5YwxW6yFVpob-fPfTx8jwfvQ0m76_j0dNkoMNYuEGiIONxROM4iVQUAxM8T0UWA89SkuvMv2mWKs2ZJzVXnAgqaAh5zCNOeMR66HGn27TpCjINW5ulbEyxUmYja1XI_z9VsZCf9VoKQkVAQy9wtxcw9XcL1slVYbc5VQV1a2XAQhYRRkLm0dsTdFm3pvLxZBCFIgooJ9RTwx2lTW2tgfxghhK57UyedOY3bo4zHPi_htgPGCCUZg</recordid><startdate>20200118</startdate><enddate>20200118</enddate><creator>Ong, Mei Shan</creator><creator>Deng, Shuo</creator><creator>Halim, Clarissa Esmeralda</creator><creator>Cai, Wanpei</creator><creator>Tan, Tuan Zea</creator><creator>Huang, Ruby Yun-Ju</creator><creator>Sethi, Gautam</creator><creator>Hooi, Shing Chuan</creator><creator>Kumar, Alan Prem</creator><creator>Yap, Celestial T</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3754-5712</orcidid><orcidid>https://orcid.org/0000-0001-6624-1593</orcidid></search><sort><creationdate>20200118</creationdate><title>Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective</title><author>Ong, Mei Shan ; 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However, in cancer cells, these mechanisms can be altered to promote tumour development and progression, whereby the functions of cytoskeletal proteins are co-opted to facilitate increased migrative and invasive capabilities, proliferation, as well as resistance to cellular and environmental stresses. Herein, we discuss the cytoskeletal responses to important intracellular stresses (such as mitochondrial, endoplasmic reticulum and oxidative stresses), and delineate the consequences of these responses, including effects on oncogenic signalling. In addition, we elaborate how the cytoskeleton and its associated molecules present themselves as therapeutic targets. 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| subjects | Actin Apoptosis Cancer Cancer therapies Cell adhesion & migration Cell division Cytokeratin Cytoskeleton Endoplasmic reticulum Filaments Intermediate filaments Intracellular Invasiveness Kinases Medical prognosis Melanoma Metastasis Microtubules Mitochondria Morphology Motility Mutation Oxidative stress Prostate Proteins Review Tumorigenesis Tumors |
| title | Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective |
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