Inhibition of the IL-18 Receptor Signaling Pathway Ameliorates Disease in a Murine Model of Rheumatoid Arthritis

Interleukin (IL)-18 expression in synovial tissue correlates with the severity of joint inflammation and the levels of pro-inflammatory cytokines. However, the role of the IL-18/IL-18 receptor-alpha (Rα) signaling pathway in autoimmune arthritis is unknown. Wild-type (WT) and IL-18Rα knockout (KO) m...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2019-12, Vol.9 (1), p.11
Hauptverfasser:	Nozaki, Yuji, Ri, Jinhai, Sakai, Kenji, Niki, Kaoru, Kinoshita, Koji, Funauchi, Masanori, Matsumura, Itaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - immunology Cartilage CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell growth Collagen Collagen (type II) Cytokines Cytokines - blood Cytokines - immunology Disease Models, Animal Enzyme-linked immunosorbent assay Experiments Female Gene expression Government agencies Inflammation Interferon-gamma - immunology Interleukin 18 Interleukin 18 receptors Interleukin 6 Interleukin-18 - biosynthesis Interleukin-18 - genetics Interleukin-18 - immunology Interleukin-18 Receptor alpha Subunit - antagonists & inhibitors Interleukin-18 Receptor alpha Subunit - biosynthesis Interleukin-18 Receptor alpha Subunit - genetics Interleukin-18 Receptor alpha Subunit - immunology Kinases Laboratory animals Lipopolysaccharides Lipopolysaccharides - pharmacology Lymph Nodes - immunology Lymphocytes Lymphocytes T Male Matrix metalloproteinase Medical research Mice Mice, Inbred DBA Mice, Knockout Polymerase chain reaction Rheumatoid arthritis RNA, Messenger - biosynthesis RNA, Messenger - genetics Signal transduction Signal Transduction - immunology Spleen Spleen - immunology Suppressor of Cytokine Signaling 3 Protein - biosynthesis Suppressor of Cytokine Signaling 3 Protein - genetics Suppressor of Cytokine Signaling 3 Protein - immunology Synovitis Tumor necrosis factor Tumor necrosis factor-TNF γ-Interferon
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