Contralateral Prophylactic Mastectomy in Women with Unilateral Breast Cancer Who Are Genetic Carriers, Have a Strong Family History or Are just Young at Presentation
The uptake of contralateral prophylactic mastectomy is rising with increasing trends that are possibly highest in the USA. Whilst its role is generally accepted in carriers of recognized high-risk predisposition genes such as and when the affected individual is premenopausal, controversy surrounds t...
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| Veröffentlicht in: | Cancers 2020-01, Vol.12 (1), p.140 |
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| creator | Teoh, Victoria Tasoulis, Marios-Konstantinos Gui, Gerald |
| description | The uptake of contralateral prophylactic mastectomy is rising with increasing trends that are possibly highest in the USA. Whilst its role is generally accepted in carriers of recognized high-risk predisposition genes such as
and
when the affected individual is premenopausal, controversy surrounds the benefit in less understood risk-profile clinical scenarios. This comprehensive review explores the current evidence underpinning the role of contralateral prophylactic mastectomy and its impact on contralateral breast cancer risk and survival in three distinct at-risk groups affected by unilateral breast cancer: known genetic carriers, those with strong familial risk but no demonstrable genetic mutation and women who are of young age at presentation. The review supports the role of contralateral prophylactic mastectomy in "high risk" groups where the evidence suggests a reduction in contralateral breast cancer risk. However, this benefit is less evident in women who are just young at presentation or those who have strong family history but no demonstrable genetic mutation. A multidisciplinary and personalized approach to support individuals in a shared-decision making process is recommended. |
| doi_str_mv | 10.3390/cancers12010140 |
| format | Article |
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and
when the affected individual is premenopausal, controversy surrounds the benefit in less understood risk-profile clinical scenarios. This comprehensive review explores the current evidence underpinning the role of contralateral prophylactic mastectomy and its impact on contralateral breast cancer risk and survival in three distinct at-risk groups affected by unilateral breast cancer: known genetic carriers, those with strong familial risk but no demonstrable genetic mutation and women who are of young age at presentation. The review supports the role of contralateral prophylactic mastectomy in "high risk" groups where the evidence suggests a reduction in contralateral breast cancer risk. However, this benefit is less evident in women who are just young at presentation or those who have strong family history but no demonstrable genetic mutation. A multidisciplinary and personalized approach to support individuals in a shared-decision making process is recommended.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers12010140</identifier><identifier>PMID: 31935898</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; BRCA1 protein ; BRCA2 protein ; Breast cancer ; Decision making ; Family medical history ; Mastectomy ; Medical diagnosis ; Meta-analysis ; Mutation ; Oophorectomy ; Patients ; Radiation therapy ; Review ; Risk groups ; Surveillance ; Womens health</subject><ispartof>Cancers, 2020-01, Vol.12 (1), p.140</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-1c764adb591b95dcac09fa8900e928bcca17a5811879929a16c76563166061133</citedby><cites>FETCH-LOGICAL-c421t-1c764adb591b95dcac09fa8900e928bcca17a5811879929a16c76563166061133</cites><orcidid>0000-0001-9453-1547</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016894/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016894/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31935898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teoh, Victoria</creatorcontrib><creatorcontrib>Tasoulis, Marios-Konstantinos</creatorcontrib><creatorcontrib>Gui, Gerald</creatorcontrib><title>Contralateral Prophylactic Mastectomy in Women with Unilateral Breast Cancer Who Are Genetic Carriers, Have a Strong Family History or Are just Young at Presentation</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>The uptake of contralateral prophylactic mastectomy is rising with increasing trends that are possibly highest in the USA. Whilst its role is generally accepted in carriers of recognized high-risk predisposition genes such as
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A multidisciplinary and personalized approach to support individuals in a shared-decision making process is recommended.</description><subject>Age</subject><subject>BRCA1 protein</subject><subject>BRCA2 protein</subject><subject>Breast cancer</subject><subject>Decision making</subject><subject>Family medical history</subject><subject>Mastectomy</subject><subject>Medical diagnosis</subject><subject>Meta-analysis</subject><subject>Mutation</subject><subject>Oophorectomy</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Review</subject><subject>Risk groups</subject><subject>Surveillance</subject><subject>Womens health</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkl1rFDEUhoMottReeycBb7xwbT5mMpMboQ62K1QUtBSvwtns2W6WmWRNMpX5Qf5Ps9sPanORBPK8L-85OYS85uyDlJqdWPAWY-KCccYr9owcCtaImVK6ev7ofkCOU9qwsqTkjWpekgPJtaxb3R6Sv13wOUIPGctOv8ewXU892Ows_Qopo81hmKjz9CoM6Okfl9f00rt7waeIhaLdPgq9Wgd6GpGeo8edQwcxuhLxPZ3DDVKgP3IM_pqeweD6ic5dyiFONMS9ajMWp19hLADkEgUT-gzZBf-KvFhBn_D47jwil2eff3bz2cW38y_d6cXMVoLnGbeNqmC5qDVf6HppwTK9glYzhlq0C2uBN1C3nLeN1kIDV0VQK8mVYopzKY_Ix1vf7bgYcGlx3xuzjW6AOJkAzvz_4t3aXIcb0zCuWl0Vg3d3BjH8HjFlM7hkse_BYxiTEVKWtjdaqYK-fYJuwhh9Kc-IumqUkKzeJTq5pWwMKUVcPYThzOymwDyZgqJ487iGB_7-z-U_MtGw4w</recordid><startdate>20200106</startdate><enddate>20200106</enddate><creator>Teoh, Victoria</creator><creator>Tasoulis, Marios-Konstantinos</creator><creator>Gui, Gerald</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9453-1547</orcidid></search><sort><creationdate>20200106</creationdate><title>Contralateral Prophylactic Mastectomy in Women with Unilateral Breast Cancer Who Are Genetic Carriers, Have a Strong Family History or Are just Young at Presentation</title><author>Teoh, Victoria ; Tasoulis, Marios-Konstantinos ; Gui, Gerald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-1c764adb591b95dcac09fa8900e928bcca17a5811879929a16c76563166061133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>BRCA1 protein</topic><topic>BRCA2 protein</topic><topic>Breast cancer</topic><topic>Decision making</topic><topic>Family medical history</topic><topic>Mastectomy</topic><topic>Medical diagnosis</topic><topic>Meta-analysis</topic><topic>Mutation</topic><topic>Oophorectomy</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Review</topic><topic>Risk groups</topic><topic>Surveillance</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teoh, Victoria</creatorcontrib><creatorcontrib>Tasoulis, Marios-Konstantinos</creatorcontrib><creatorcontrib>Gui, Gerald</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teoh, Victoria</au><au>Tasoulis, Marios-Konstantinos</au><au>Gui, Gerald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contralateral Prophylactic Mastectomy in Women with Unilateral Breast Cancer Who Are Genetic Carriers, Have a Strong Family History or Are just Young at Presentation</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2020-01-06</date><risdate>2020</risdate><volume>12</volume><issue>1</issue><spage>140</spage><pages>140-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>The uptake of contralateral prophylactic mastectomy is rising with increasing trends that are possibly highest in the USA. Whilst its role is generally accepted in carriers of recognized high-risk predisposition genes such as
and
when the affected individual is premenopausal, controversy surrounds the benefit in less understood risk-profile clinical scenarios. This comprehensive review explores the current evidence underpinning the role of contralateral prophylactic mastectomy and its impact on contralateral breast cancer risk and survival in three distinct at-risk groups affected by unilateral breast cancer: known genetic carriers, those with strong familial risk but no demonstrable genetic mutation and women who are of young age at presentation. The review supports the role of contralateral prophylactic mastectomy in "high risk" groups where the evidence suggests a reduction in contralateral breast cancer risk. However, this benefit is less evident in women who are just young at presentation or those who have strong family history but no demonstrable genetic mutation. A multidisciplinary and personalized approach to support individuals in a shared-decision making process is recommended.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31935898</pmid><doi>10.3390/cancers12010140</doi><orcidid>https://orcid.org/0000-0001-9453-1547</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age BRCA1 protein BRCA2 protein Breast cancer Decision making Family medical history Mastectomy Medical diagnosis Meta-analysis Mutation Oophorectomy Patients Radiation therapy Review Risk groups Surveillance Womens health |
| title | Contralateral Prophylactic Mastectomy in Women with Unilateral Breast Cancer Who Are Genetic Carriers, Have a Strong Family History or Are just Young at Presentation |
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