Genome-wide analysis and functional prediction of the estrogen-regulated transcriptional response in the mouse uterus

The ovarian hormones estrogen and progesterone orchestrate the transcriptional programs required to direct functions of the uterus for initiation and maintenance of pregnancy. Estrogen, acting via estrogen receptor alpha, regulates gene expression by activating and repressing distinct genes involved...

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Veröffentlicht in:	Biology of reproduction 2020-02, Vol.102 (2), p.327-338
Hauptverfasser:	Vasquez, Yasmin M, Nandu, Tulip S, Kelleher, Andrew M, Ramos, Enrique I, Gadad, Shrikanth S, Kraus, W. Lee
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Biology Cancer Cell division Disease prevention Endometrial cancer Endometrium estradiol/estradiol receptor Estrogen receptors Estrogens Gene expression Gene regulation Genetic aspects Genome-wide association studies Genomes Genomics Hormones KCNQ1OT1 protein Non-coding RNA Observations Ovariectomy Phenotypes Physiological aspects Physiology Potassium channels (voltage-gated) Pregnancy Progesterone Proteins Reproductive health RESEARCH ARTICLE Rodents Transcription Transcription (Genetics) transcriptional regulation Transcriptomes Uterine cancer Uterus
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