Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumption

Murine models of chronic alcohol consumption are frequently used to investigate alcoholic liver injury and define new therapeutic targets. Lieber-DeCarli diet (LD) and Meadows-Cook diet (MC) are the most accepted models of chronic alcohol consumption. It is unclear how similar these models are at th...

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Veröffentlicht in:	Scientific reports 2020-02, Vol.10 (1), p.2451, Article 2451
Hauptverfasser:	Vogle, Alyx, Qian, Tongqi, Zhu, Shijia, Burnett, Elizabeth, Fey, Holger, Zhu, Zhibin, Keshavarzian, Ali, Shaikh, Maliha, Hoshida, Yujin, Kim, Miran, Aloman, Costica
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/256/2515 692/4020/4021/1607/1608 Alcohol Drinking - genetics Alcohol Drinking - immunology Alcohol Drinking - pathology Alcohol use Alcoholism - etiology Alcoholism - genetics Alcoholism - immunology Alcoholism - pathology Alcohols Animal models Animals CD45 antigen Chemokines Chronic Disease Diet Disease Models, Animal Fatty liver Female Gene expression Humanities and Social Sciences Humans Liver Liver - immunology Liver - metabolism Liver - pathology Liver diseases Liver Diseases, Alcoholic - etiology Liver Diseases, Alcoholic - genetics Liver Diseases, Alcoholic - immunology Liver Diseases, Alcoholic - pathology Meadows Mice Mice, Inbred C57BL Monocytes multidisciplinary Ribonucleic acid RNA Science Science (multidisciplinary) Steatosis Therapeutic applications Transcriptome Transcriptomics
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