Magnetometer with nitrogen-vacancy center in a bulk diamond for detecting magnetic nanoparticles in biomedical applications
We developed a novel magnetometer that employs negatively charged nitrogen-vacancy (NV − ) centers in diamond, to detect the magnetic field generated by magnetic nanoparticles (MNPs) for biomedical applications. The compact probe system is integrated into a fiber-optics platform allowing for a compa...
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| Veröffentlicht in: | Scientific reports 2020-02, Vol.10 (1), p.2483-2483, Article 2483 |
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| creator | Kuwahata, Akihiro Kitaizumi, Takahiro Saichi, Kota Sato, Takumi Igarashi, Ryuji Ohshima, Takeshi Masuyama, Yuta Iwasaki, Takayuki Hatano, Mutsuko Jelezko, Fedor Kusakabe, Moriaki Yatsui, Takashi Sekino, Masaki |
| description | We developed a novel magnetometer that employs negatively charged nitrogen-vacancy (NV
−
) centers in diamond, to detect the magnetic field generated by magnetic nanoparticles (MNPs) for biomedical applications. The compact probe system is integrated into a fiber-optics platform allowing for a compact design. To detect signals from the MNPs effectively, we demonstrated, for the first time, the application of an alternating current (AC) magnetic field generated by the excitation coil of several hundred microteslas for the magnetization of MNPs in diamond quantum sensing. In the lock-in detection system, the minimum detectable AC magnetic field (at a frequency of 1.025 kHz) was approximately 57.6 nT for one second measurement time. We were able to detect the micromolar concentration of MNPs at distances of a few millimeters. These results indicate that the magnetometer with the NV
−
centers can detect the tiny amounts of MNPs, thereby offering potential for future biomedical applications. |
| doi_str_mv | 10.1038/s41598-020-59064-6 |
| format | Article |
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−
) centers in diamond, to detect the magnetic field generated by magnetic nanoparticles (MNPs) for biomedical applications. The compact probe system is integrated into a fiber-optics platform allowing for a compact design. To detect signals from the MNPs effectively, we demonstrated, for the first time, the application of an alternating current (AC) magnetic field generated by the excitation coil of several hundred microteslas for the magnetization of MNPs in diamond quantum sensing. In the lock-in detection system, the minimum detectable AC magnetic field (at a frequency of 1.025 kHz) was approximately 57.6 nT for one second measurement time. We were able to detect the micromolar concentration of MNPs at distances of a few millimeters. These results indicate that the magnetometer with the NV
−
centers can detect the tiny amounts of MNPs, thereby offering potential for future biomedical applications.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-59064-6</identifier><identifier>PMID: 32051447</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/1647/1888 ; 639/166/985 ; 9/10 ; Fiber optics ; Humanities and Social Sciences ; Magnetic fields ; Magnetometers ; multidisciplinary ; Nanoparticles ; Nitrogen ; Optics ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.2483-2483, Article 2483</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-8def11ca1800a40030fbb48b5f3cac4a1126e6ebee57c8df8e5a1cf890e9eb773</citedby><cites>FETCH-LOGICAL-c518t-8def11ca1800a40030fbb48b5f3cac4a1126e6ebee57c8df8e5a1cf890e9eb773</cites><orcidid>0000-0002-7850-3164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015934/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015934/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32051447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuwahata, Akihiro</creatorcontrib><creatorcontrib>Kitaizumi, Takahiro</creatorcontrib><creatorcontrib>Saichi, Kota</creatorcontrib><creatorcontrib>Sato, Takumi</creatorcontrib><creatorcontrib>Igarashi, Ryuji</creatorcontrib><creatorcontrib>Ohshima, Takeshi</creatorcontrib><creatorcontrib>Masuyama, Yuta</creatorcontrib><creatorcontrib>Iwasaki, Takayuki</creatorcontrib><creatorcontrib>Hatano, Mutsuko</creatorcontrib><creatorcontrib>Jelezko, Fedor</creatorcontrib><creatorcontrib>Kusakabe, Moriaki</creatorcontrib><creatorcontrib>Yatsui, Takashi</creatorcontrib><creatorcontrib>Sekino, Masaki</creatorcontrib><title>Magnetometer with nitrogen-vacancy center in a bulk diamond for detecting magnetic nanoparticles in biomedical applications</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>We developed a novel magnetometer that employs negatively charged nitrogen-vacancy (NV
−
) centers in diamond, to detect the magnetic field generated by magnetic nanoparticles (MNPs) for biomedical applications. The compact probe system is integrated into a fiber-optics platform allowing for a compact design. To detect signals from the MNPs effectively, we demonstrated, for the first time, the application of an alternating current (AC) magnetic field generated by the excitation coil of several hundred microteslas for the magnetization of MNPs in diamond quantum sensing. In the lock-in detection system, the minimum detectable AC magnetic field (at a frequency of 1.025 kHz) was approximately 57.6 nT for one second measurement time. We were able to detect the micromolar concentration of MNPs at distances of a few millimeters. These results indicate that the magnetometer with the NV
−
centers can detect the tiny amounts of MNPs, thereby offering potential for future biomedical applications.</description><subject>631/1647/1888</subject><subject>639/166/985</subject><subject>9/10</subject><subject>Fiber optics</subject><subject>Humanities and Social Sciences</subject><subject>Magnetic fields</subject><subject>Magnetometers</subject><subject>multidisciplinary</subject><subject>Nanoparticles</subject><subject>Nitrogen</subject><subject>Optics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1TAQhS0EolXpC7BAltiwCfg3cTZIqIKCVMQG1tbEmaQuiR3spKji5et7bymFBd54pPnO8YwPIc85e82ZNG-y4ro1FROs0i2rVVU_IseCKV0JKcTjB_UROc35ipWjRat4-5QcScE0V6o5Jr8-wxhwjTOumOhPv17S4NcURwzVNTgI7oY6DLumDxRot03fae9hjqGnQ0y0L0K3-jDSee_kHQ0Q4gKplBPmnazzxb_3DiYKyzKVYvUx5GfkyQBTxtO7-4R8-_D-69nH6uLL-aezdxeV09yslelx4NwBN4yBYkyyoeuU6fQgHTgFnIsaa-wQdeNMPxjUwN1gWoYtdk0jT8jbg--ydWWO3ToJJrskP0O6sRG8_bsT_KUd47VtWPljqYrBqzuDFH9smFc7--xwmiBg3LIVUqtGam1MQV_-g17FLYWy3p5ibV1iKJQ4UC7FnBMO98NwZnfx2kO8tsRr9_HauohePFzjXvI7zALIA5BLK4yY_rz9H9tbtW20KQ</recordid><startdate>20200212</startdate><enddate>20200212</enddate><creator>Kuwahata, Akihiro</creator><creator>Kitaizumi, Takahiro</creator><creator>Saichi, Kota</creator><creator>Sato, Takumi</creator><creator>Igarashi, Ryuji</creator><creator>Ohshima, Takeshi</creator><creator>Masuyama, Yuta</creator><creator>Iwasaki, Takayuki</creator><creator>Hatano, Mutsuko</creator><creator>Jelezko, Fedor</creator><creator>Kusakabe, Moriaki</creator><creator>Yatsui, Takashi</creator><creator>Sekino, Masaki</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7850-3164</orcidid></search><sort><creationdate>20200212</creationdate><title>Magnetometer with nitrogen-vacancy center in a bulk diamond for detecting magnetic nanoparticles in biomedical applications</title><author>Kuwahata, Akihiro ; 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−
) centers in diamond, to detect the magnetic field generated by magnetic nanoparticles (MNPs) for biomedical applications. The compact probe system is integrated into a fiber-optics platform allowing for a compact design. To detect signals from the MNPs effectively, we demonstrated, for the first time, the application of an alternating current (AC) magnetic field generated by the excitation coil of several hundred microteslas for the magnetization of MNPs in diamond quantum sensing. In the lock-in detection system, the minimum detectable AC magnetic field (at a frequency of 1.025 kHz) was approximately 57.6 nT for one second measurement time. We were able to detect the micromolar concentration of MNPs at distances of a few millimeters. These results indicate that the magnetometer with the NV
−
centers can detect the tiny amounts of MNPs, thereby offering potential for future biomedical applications.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32051447</pmid><doi>10.1038/s41598-020-59064-6</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7850-3164</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/1647/1888 639/166/985 9/10 Fiber optics Humanities and Social Sciences Magnetic fields Magnetometers multidisciplinary Nanoparticles Nitrogen Optics Science Science (multidisciplinary) |
| title | Magnetometer with nitrogen-vacancy center in a bulk diamond for detecting magnetic nanoparticles in biomedical applications |
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