Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes

RAF family kinases are RAS-activated switches that initiate signalling through the MAP kinase cascade to control cellular proliferation, differentiation and survival 1 – 3 . RAF activity is tightly regulated and inappropriate activation is a frequent cause of cancer 4 – 6 ; however, the structural b...

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Veröffentlicht in:	Nature (London) 2019-11, Vol.575 (7783), p.545-550
Hauptverfasser:	Park, Eunyoung, Rawson, Shaun, Li, Kunhua, Kim, Byeong-Won, Ficarro, Scott B., Pino, Gonzalo Gonzalez-Del, Sharif, Humayun, Marto, Jarrod A., Jeon, Hyesung, Eck, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 101/28 101/58 14-3-3 protein 14-3-3 Proteins - antagonists & inhibitors 14-3-3 Proteins - chemistry 14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism 631/535/1258/1259 631/67/395 631/80/86/2368 82/16 82/29 82/80 82/83 Analysis Automation Binding proteins Binding Sites Cancer Cell Transformation, Neoplastic - genetics Cryoelectron Microscopy Cysteine Dimerization Dimers Disruption Electron microscopy Humanities and Social Sciences Humans Kinases MAP kinase MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 1 - chemistry MAP Kinase Kinase 1 - genetics MAP Kinase Kinase 1 - metabolism Mass spectrometry Microscopy Mitogen-activated protein kinases Models, Molecular multidisciplinary Mutation Phosphorylation Protein Binding Protein Domains Protein Multimerization Proteins Proteomics Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - chemistry Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Raf protein Science Science (multidisciplinary) Scientific imaging Sequestering Software Structure Switches
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