The anti-MRSA compound 3-O-alpha-L-(2″,3″-di-p-coumaroyl)rhamnoside (KCR) inhibits protein synthesis in Staphylococcus aureus

Methicillin-resistant S aureus (MRSA) contributes to patient mortality and extended hospital stays. 3-O-alpha-L-(2″,3″-di-p-coumaroyl)rhamnoside (KCR) is a natural product antibiotic that is effective against MRSA but has no known mechanism of action (MOA). We used proteomics to identify the MOA for...

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Veröffentlicht in:	Journal of proteomics 2020-01, Vol.210, p.103539-103539, Article 103539
Hauptverfasser:	Carruthers, Nicholas J., Stemmer, Paul M., Media, Joe, Swartz, Ken, Wang, Xiaojuan, Aube, Nicholas, Hamann, Mark T., Valeriote, Frederick, Shaw, Jiajiu
Format:	Artikel
Sprache:	eng
Schlagworte:	3-O-alpha-L-(2″,3″-di-p-coumaroyl)rhamnoside aminoacyl tRNA ligases Anti-Bacterial Agents - pharmacology antibiotic resistance Bacterial Proteins - metabolism enzyme activity hospitals Humans in vitro studies inhibitory concentration 50 Kaempferols - pharmacology KCR luciferase mass spectrometry Mechanism of action methicillin Methicillin-resistant methicillin-resistant Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - isolation & purification Methicillin-Resistant Staphylococcus aureus - metabolism Microbial Sensitivity Tests - methods mortality oxacillin patients Protein Biosynthesis protein synthesis Protein Synthesis Inhibitors - pharmacology Proteomics Proteomics - methods Rhamnose - analogs & derivatives Rhamnose - pharmacology ribosomal RNA ribosomes Staphylococcal Infections - drug therapy Staphylococcal Infections - metabolism Staphylococcal Infections - microbiology Staphylococcus aureus stereoisomers translation (genetics)
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