Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer’s disease-like pathology

•Sporadic Alzheimer’s disease (sAD) is difficult to model in animals.•We produced a conditional over-expressing, miR-34a mouse to model sAD.•miR-34a over-expression results in a rapid cognitive impairment.•miR-34a over-expression also induces AD pathology in various cognitive brain regions.•Inducibl...

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Veröffentlicht in:	Brain research 2019-10, Vol.1721, p.146327-146327, Article 146327
Hauptverfasser:	Sarkar, S., Engler-Chiurazzi, E.B., Cavendish, J.Z., Povroznik, J.M., Russell, A.E., Quintana, D.D., Mathers, P.H., Simpkins, J.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM10 Late-onset Alzheimer’s disease Memory-related behaviors microRNA miR-34a NMDAR 2B SIRT1 Tau phosphorylation β amyloid
Online-Zugang:	Volltext
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