Crocetin Extracted from Saffron Shows Antitumor Effects in Models of Human Glioblastoma

Over recent years, many authors discussed the effects of different natural compounds on glioblastoma (GBM). Due to its capacity to impair survival and progression of different cancer types, saffron extract (SE), named crocetin (CCT), is particularly noteworthy. In this work, we elucidated the antitu...

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Veröffentlicht in:	International journal of molecular sciences 2020-01, Vol.21 (2), p.423
Hauptverfasser:	Colapietro, Alessandro, Mancini, Andrea, Vitale, Flora, Martellucci, Stefano, Angelucci, Adriano, Llorens, Silvia, Mattei, Vincenzo, Gravina, Giovanni Luca, Alonso, Gonzalo Luis, Festuccia, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis Apoptosis - drug effects Biomarkers, Tumor - metabolism Brain cancer Brain Neoplasms - drug therapy Carotenoids - isolation & purification Carotenoids - pharmacology Carotenoids - therapeutic use CD44 antigen CD90 antigen Cell Differentiation - drug effects Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Shape - drug effects Crocus - chemistry CXCR4 protein Cytology Disease-Free Survival Enzymes Epigenetics Fatty Acid Synthases - metabolism Fatty-acid synthase Female Gene expression Glioblastoma Glioblastoma - drug therapy Glioma Glioma cells Glycoproteins Histone deacetylase Humans Hyaluronan Receptors - metabolism In vivo methods and tests Injections, Subcutaneous Inoculation Kaplan-Meier Estimate Luminescent Measurements Mesenchyme Mesoderm - pathology Mice, Nude Morphology Neurofilaments Neuromodulation Neurons - drug effects Neurons - metabolism Oct-4 protein Proteins Radiation therapy Saffron Stem cells Survival Temozolomide Tubulin Tumor cell lines Tumors Western blotting Wound healing Xenografts Xenotransplantation
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