Chronic kidney disease attenuates the impact of obesity on quality of life
The impact of obesity on health-related quality of life (HRQoL) in chronic kidney disease (CKD) population has not been elucidated, despite the impairment of HRQoL in the obese among general population. We hypothesized that the impact of obesity on HRQoL might be confounded by impaired renal functio...
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| description | The impact of obesity on health-related quality of life (HRQoL) in chronic kidney disease (CKD) population has not been elucidated, despite the impairment of HRQoL in the obese among general population. We hypothesized that the impact of obesity on HRQoL might be confounded by impaired renal function in CKD population, and that CKD would attenuate the impact of obesity on HRQoL. To compare the impact of obesity on HRQoL according to kidney function, 17,001 subjects from Korea National Health and Nutrition Examination Survey (2008–2011) were categorized by estimated glomerular filtration rate (eGFR), as follows: group 1, eGFR ≥ 90 mL/min/1.73 m
2
; group 2, eGFR of 60–89 mL/min/1.73 m
2
; group 3, eGFR |
| doi_str_mv | 10.1038/s41598-020-59382-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7012880</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2354162989</sourcerecordid><originalsourceid>FETCH-LOGICAL-c522t-ff4a67317a5bf7553275d93e897b15629de5ae5aecfe5781167341494f0d13d63</originalsourceid><addsrcrecordid>eNp9kUtLJDEUhYOMqKh_wIUEZjOb0jw7lc3A0IwvBDe6DumqGztanbRJaqD_vWnb17gwBHLhfDn3Xg5CR5ScUMLb0yyo1G1DGGmk5i1r9BbaY0TIhnHGfnyqd9Fhzg-kHsm0oHoH7fIqKkbIHrqazlMMvsOPvg-wwr3PYDNgWwqE0RbIuMwB-8XSdgVHh-MMsi8rHAN-Gu3wUjo8eAcHaNvZIcPh67uP7s7-3k4vmuub88vpn-umk4yVxjlhJ4pTZeXMKSk5U7LXHFqtZlROmO5B2vXtHEjVUlphQYUWjvSU9xO-j35vfJfjbAF9B6EkO5hl8gubViZab_5Xgp-b-_jPKEJZ25Jq8OvVIMWnEXIxC587GAYbII7ZMC4FrYO0uqI_v6APcUyhrremuJxILlSl2IbqUsw5gXsfhhKzTsts0jI1LfOSlllbH39e4_3LWzYV4BsgVyncQ_ro_Y3tM3o2n2c</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2353565347</pqid></control><display><type>article</type><title>Chronic kidney disease attenuates the impact of obesity on quality of life</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Suh, Sang Heon ; Choi, Hong Sang ; Kim, Chang Seong ; Bae, Eun Hui ; Ma, Seong Kwon ; Lee, Dae Ho ; Kim, Soo Wan</creator><creatorcontrib>Suh, Sang Heon ; Choi, Hong Sang ; Kim, Chang Seong ; Bae, Eun Hui ; Ma, Seong Kwon ; Lee, Dae Ho ; Kim, Soo Wan</creatorcontrib><description>The impact of obesity on health-related quality of life (HRQoL) in chronic kidney disease (CKD) population has not been elucidated, despite the impairment of HRQoL in the obese among general population. We hypothesized that the impact of obesity on HRQoL might be confounded by impaired renal function in CKD population, and that CKD would attenuate the impact of obesity on HRQoL. To compare the impact of obesity on HRQoL according to kidney function, 17,001 subjects from Korea National Health and Nutrition Examination Survey (2008–2011) were categorized by estimated glomerular filtration rate (eGFR), as follows: group 1, eGFR ≥ 90 mL/min/1.73 m
2
; group 2, eGFR of 60–89 mL/min/1.73 m
2
; group 3, eGFR < 60 mL/min/1.73 m
2
. The association between obesity parameters (body mass index, waist circumference and, truncal fat mass) and HRQoL parameters (EQ-5D index and EQ-VAS) were cross-sectionally analyzed. Despite robust correlations between obesity parameters and low EQ-5D index or EQ-VAS in general population, no significant association was observed in group 3 population. Impact of obesity on HRQoL in CKD population was only limitedly observed in the mobility domain of EQ-5D, as mobility limitation was associated with increased body mass index or waist circumference regardless of kidney function. Therefore, the impact of obesity on HRQoL seems significantly attenuated in CKD population, suggesting that the risk of obesity should not be over-estimated in patients with CKD, especially with respect to HRQoL.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-59382-9</identifier><identifier>PMID: 32047200</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4022/1585/104/1586 ; 692/4022/272/1684/1587 ; Adult ; Body fat ; Body mass index ; Epidermal growth factor receptors ; Female ; Glomerular filtration rate ; Humanities and Social Sciences ; Humans ; Kidney diseases ; Kidneys ; Male ; Middle Aged ; Mobility ; multidisciplinary ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Population ; Quality of Life ; Renal function ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - epidemiology ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.2375-2375, Article 2375</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-ff4a67317a5bf7553275d93e897b15629de5ae5aecfe5781167341494f0d13d63</citedby><cites>FETCH-LOGICAL-c522t-ff4a67317a5bf7553275d93e897b15629de5ae5aecfe5781167341494f0d13d63</cites><orcidid>0000-0002-8832-3052 ; 0000-0002-3540-9004</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012880/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012880/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32047200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suh, Sang Heon</creatorcontrib><creatorcontrib>Choi, Hong Sang</creatorcontrib><creatorcontrib>Kim, Chang Seong</creatorcontrib><creatorcontrib>Bae, Eun Hui</creatorcontrib><creatorcontrib>Ma, Seong Kwon</creatorcontrib><creatorcontrib>Lee, Dae Ho</creatorcontrib><creatorcontrib>Kim, Soo Wan</creatorcontrib><title>Chronic kidney disease attenuates the impact of obesity on quality of life</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The impact of obesity on health-related quality of life (HRQoL) in chronic kidney disease (CKD) population has not been elucidated, despite the impairment of HRQoL in the obese among general population. We hypothesized that the impact of obesity on HRQoL might be confounded by impaired renal function in CKD population, and that CKD would attenuate the impact of obesity on HRQoL. To compare the impact of obesity on HRQoL according to kidney function, 17,001 subjects from Korea National Health and Nutrition Examination Survey (2008–2011) were categorized by estimated glomerular filtration rate (eGFR), as follows: group 1, eGFR ≥ 90 mL/min/1.73 m
2
; group 2, eGFR of 60–89 mL/min/1.73 m
2
; group 3, eGFR < 60 mL/min/1.73 m
2
. The association between obesity parameters (body mass index, waist circumference and, truncal fat mass) and HRQoL parameters (EQ-5D index and EQ-VAS) were cross-sectionally analyzed. Despite robust correlations between obesity parameters and low EQ-5D index or EQ-VAS in general population, no significant association was observed in group 3 population. Impact of obesity on HRQoL in CKD population was only limitedly observed in the mobility domain of EQ-5D, as mobility limitation was associated with increased body mass index or waist circumference regardless of kidney function. Therefore, the impact of obesity on HRQoL seems significantly attenuated in CKD population, suggesting that the risk of obesity should not be over-estimated in patients with CKD, especially with respect to HRQoL.</description><subject>692/4022/1585/104/1586</subject><subject>692/4022/272/1684/1587</subject><subject>Adult</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Epidermal growth factor receptors</subject><subject>Female</subject><subject>Glomerular filtration rate</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mobility</subject><subject>multidisciplinary</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Population</subject><subject>Quality of Life</subject><subject>Renal function</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtLJDEUhYOMqKh_wIUEZjOb0jw7lc3A0IwvBDe6DumqGztanbRJaqD_vWnb17gwBHLhfDn3Xg5CR5ScUMLb0yyo1G1DGGmk5i1r9BbaY0TIhnHGfnyqd9Fhzg-kHsm0oHoH7fIqKkbIHrqazlMMvsOPvg-wwr3PYDNgWwqE0RbIuMwB-8XSdgVHh-MMsi8rHAN-Gu3wUjo8eAcHaNvZIcPh67uP7s7-3k4vmuub88vpn-umk4yVxjlhJ4pTZeXMKSk5U7LXHFqtZlROmO5B2vXtHEjVUlphQYUWjvSU9xO-j35vfJfjbAF9B6EkO5hl8gubViZab_5Xgp-b-_jPKEJZ25Jq8OvVIMWnEXIxC587GAYbII7ZMC4FrYO0uqI_v6APcUyhrremuJxILlSl2IbqUsw5gXsfhhKzTsts0jI1LfOSlllbH39e4_3LWzYV4BsgVyncQ_ro_Y3tM3o2n2c</recordid><startdate>20200211</startdate><enddate>20200211</enddate><creator>Suh, Sang Heon</creator><creator>Choi, Hong Sang</creator><creator>Kim, Chang Seong</creator><creator>Bae, Eun Hui</creator><creator>Ma, Seong Kwon</creator><creator>Lee, Dae Ho</creator><creator>Kim, Soo Wan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8832-3052</orcidid><orcidid>https://orcid.org/0000-0002-3540-9004</orcidid></search><sort><creationdate>20200211</creationdate><title>Chronic kidney disease attenuates the impact of obesity on quality of life</title><author>Suh, Sang Heon ; 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We hypothesized that the impact of obesity on HRQoL might be confounded by impaired renal function in CKD population, and that CKD would attenuate the impact of obesity on HRQoL. To compare the impact of obesity on HRQoL according to kidney function, 17,001 subjects from Korea National Health and Nutrition Examination Survey (2008–2011) were categorized by estimated glomerular filtration rate (eGFR), as follows: group 1, eGFR ≥ 90 mL/min/1.73 m
2
; group 2, eGFR of 60–89 mL/min/1.73 m
2
; group 3, eGFR < 60 mL/min/1.73 m
2
. The association between obesity parameters (body mass index, waist circumference and, truncal fat mass) and HRQoL parameters (EQ-5D index and EQ-VAS) were cross-sectionally analyzed. Despite robust correlations between obesity parameters and low EQ-5D index or EQ-VAS in general population, no significant association was observed in group 3 population. Impact of obesity on HRQoL in CKD population was only limitedly observed in the mobility domain of EQ-5D, as mobility limitation was associated with increased body mass index or waist circumference regardless of kidney function. Therefore, the impact of obesity on HRQoL seems significantly attenuated in CKD population, suggesting that the risk of obesity should not be over-estimated in patients with CKD, especially with respect to HRQoL.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32047200</pmid><doi>10.1038/s41598-020-59382-9</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-8832-3052</orcidid><orcidid>https://orcid.org/0000-0002-3540-9004</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/4022/1585/104/1586 692/4022/272/1684/1587 Adult Body fat Body mass index Epidermal growth factor receptors Female Glomerular filtration rate Humanities and Social Sciences Humans Kidney diseases Kidneys Male Middle Aged Mobility multidisciplinary Obesity Obesity - complications Obesity - epidemiology Population Quality of Life Renal function Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - epidemiology Science Science (multidisciplinary) |
| title | Chronic kidney disease attenuates the impact of obesity on quality of life |
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