Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study
We investigated the relationship of changes in Metabolic syndrome (MetS) and its components with the risk of type 2 diabetes (T2D) in South Korea. Records of 10,806,716 adults aged ≥ 20 years without a history of T2D between 2009 and 2015 were retrieved from database of the South Korean National Hea...
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| Veröffentlicht in: | Scientific reports 2020-02, Vol.10 (1), p.2313-2313, Article 2313 |
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| description | We investigated the relationship of changes in Metabolic syndrome (MetS) and its components with the risk of type 2 diabetes (T2D) in South Korea. Records of 10,806,716 adults aged ≥ 20 years without a history of T2D between 2009 and 2015 were retrieved from database of the South Korean National Health Insurance Service and analyzed. Changes in metabolic components were monitored over a two-year period with follow-up occurring at an average of 4.087 years. During the follow-up period, 848,859 individuals were diagnosed with T2D. The risk of diabetes was lowered with a decrease in the number of MetS components at baseline and the second visit (
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| doi_str_mv | 10.1038/s41598-020-59203-z |
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p
for trend <0.0001). Multivariable-adjusted HRs for incident diabetes were 0.645 among individuals with reduced number of MetS components, 0.54 for those with improvement in elevated fasting glucose, 0.735 for those with improvement in elevated triglycerides, 0.746 for those with improvement in elevated blood pressure, 0.763 for those with improvement in reduced HDL-cholesterol, and 0.92 for those with improvement in abdominal obesity compared with those manifesting them at both time points. In conclusion, changes in metabolic syndrome and its components were significantly associated with the development of T2D. Improvement in MetS and its components attenuated the risk of diabetes.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-59203-z</identifier><identifier>PMID: 32047219</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743/137 ; 692/163/2743/2037 ; Adult ; Blood pressure ; Cholesterol ; Cohort analysis ; Cohort Studies ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - pathology ; Female ; Health risks ; High density lipoprotein ; Humanities and Social Sciences ; Humans ; Hypertension ; Hypertension - physiopathology ; Incidence ; Male ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - complications ; Middle Aged ; multidisciplinary ; Obesity - physiopathology ; Prognosis ; Republic of Korea - epidemiology ; Risk Factors ; Science ; Science (multidisciplinary) ; Triglycerides ; Young Adult</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.2313-2313, Article 2313</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-50dcdb768b37eeaa0b0eabc46e0c63f0e2d67794e293b349b6f5c3ae576461c23</citedby><cites>FETCH-LOGICAL-c522t-50dcdb768b37eeaa0b0eabc46e0c63f0e2d67794e293b349b6f5c3ae576461c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012827/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012827/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32047219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Min-Kyung</creatorcontrib><creatorcontrib>Han, Kyungdo</creatorcontrib><creatorcontrib>Kim, Mee Kyoung</creatorcontrib><creatorcontrib>Koh, Eun Sil</creatorcontrib><creatorcontrib>Kim, Eun Sook</creatorcontrib><creatorcontrib>Nam, Ga Eun</creatorcontrib><creatorcontrib>Kwon, Hyuk-Sang</creatorcontrib><title>Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>We investigated the relationship of changes in Metabolic syndrome (MetS) and its components with the risk of type 2 diabetes (T2D) in South Korea. Records of 10,806,716 adults aged ≥ 20 years without a history of T2D between 2009 and 2015 were retrieved from database of the South Korean National Health Insurance Service and analyzed. Changes in metabolic components were monitored over a two-year period with follow-up occurring at an average of 4.087 years. During the follow-up period, 848,859 individuals were diagnosed with T2D. The risk of diabetes was lowered with a decrease in the number of MetS components at baseline and the second visit (
p
for trend <0.0001). Multivariable-adjusted HRs for incident diabetes were 0.645 among individuals with reduced number of MetS components, 0.54 for those with improvement in elevated fasting glucose, 0.735 for those with improvement in elevated triglycerides, 0.746 for those with improvement in elevated blood pressure, 0.763 for those with improvement in reduced HDL-cholesterol, and 0.92 for those with improvement in abdominal obesity compared with those manifesting them at both time points. In conclusion, changes in metabolic syndrome and its components were significantly associated with the development of T2D. Improvement in MetS and its components attenuated the risk of diabetes.</description><subject>692/163/2743/137</subject><subject>692/163/2743/2037</subject><subject>Adult</subject><subject>Blood pressure</subject><subject>Cholesterol</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Female</subject><subject>Health risks</subject><subject>High density lipoprotein</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - physiopathology</subject><subject>Incidence</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Obesity - physiopathology</subject><subject>Prognosis</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Triglycerides</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctuFDEQRS0EItGQH2CBLLFh0-B3T7NAQiNeUiQ2sLb8qM446bYH2x00-Xo8mRACC7xxyffUdZUuQs8peU0JX78pgsph3RFGOjkwwrubR-iUESE7xhl7_KA-QWelXJJ2JBsEHZ6iE97EntHhFF1ttiZeQMEh4hmqsWkKDpd99DnNgE30ONSCXZp3KUJs5eGpbgHnUK5wGnHd7wAz7IOxUKG8xQZHU0OKP4OH1rhNueJSF79_hp6MZipwdnev0PePH75tPnfnXz992bw_75xkrHaSeOdtr9aW9wDGEEvAWCcUEKf4SIB51feDADZwy8Vg1SgdNyB7JRR1jK_Qu6PvbrEzeNfGzmbSuxxmk_c6maD_VmLY6ot0rXtC2Zr1zeDVnUFOPxYoVc-hOJgmEyEtRTMuBVVcUNHQl_-gl2nJsa13oLhUt-QKsSPlciolw3g_DCX6EKc-xqlbnPo2Tn3Tml48XOO-5Xd4DeBHoDSphZj__P0f21-E3qzm</recordid><startdate>20200211</startdate><enddate>20200211</enddate><creator>Lee, Min-Kyung</creator><creator>Han, Kyungdo</creator><creator>Kim, Mee Kyoung</creator><creator>Koh, Eun Sil</creator><creator>Kim, Eun Sook</creator><creator>Nam, Ga Eun</creator><creator>Kwon, Hyuk-Sang</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200211</creationdate><title>Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study</title><author>Lee, Min-Kyung ; Han, Kyungdo ; Kim, Mee Kyoung ; Koh, Eun Sil ; Kim, Eun Sook ; Nam, Ga Eun ; Kwon, Hyuk-Sang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-50dcdb768b37eeaa0b0eabc46e0c63f0e2d67794e293b349b6f5c3ae576461c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/163/2743/137</topic><topic>692/163/2743/2037</topic><topic>Adult</topic><topic>Blood pressure</topic><topic>Cholesterol</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Female</topic><topic>Health risks</topic><topic>High density lipoprotein</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - physiopathology</topic><topic>Incidence</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Obesity - physiopathology</topic><topic>Prognosis</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Triglycerides</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Min-Kyung</creatorcontrib><creatorcontrib>Han, Kyungdo</creatorcontrib><creatorcontrib>Kim, Mee Kyoung</creatorcontrib><creatorcontrib>Koh, Eun Sil</creatorcontrib><creatorcontrib>Kim, Eun Sook</creatorcontrib><creatorcontrib>Nam, Ga Eun</creatorcontrib><creatorcontrib>Kwon, Hyuk-Sang</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Min-Kyung</au><au>Han, Kyungdo</au><au>Kim, Mee Kyoung</au><au>Koh, Eun Sil</au><au>Kim, Eun Sook</au><au>Nam, Ga Eun</au><au>Kwon, Hyuk-Sang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-02-11</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>2313</spage><epage>2313</epage><pages>2313-2313</pages><artnum>2313</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>We investigated the relationship of changes in Metabolic syndrome (MetS) and its components with the risk of type 2 diabetes (T2D) in South Korea. Records of 10,806,716 adults aged ≥ 20 years without a history of T2D between 2009 and 2015 were retrieved from database of the South Korean National Health Insurance Service and analyzed. Changes in metabolic components were monitored over a two-year period with follow-up occurring at an average of 4.087 years. During the follow-up period, 848,859 individuals were diagnosed with T2D. The risk of diabetes was lowered with a decrease in the number of MetS components at baseline and the second visit (
p
for trend <0.0001). Multivariable-adjusted HRs for incident diabetes were 0.645 among individuals with reduced number of MetS components, 0.54 for those with improvement in elevated fasting glucose, 0.735 for those with improvement in elevated triglycerides, 0.746 for those with improvement in elevated blood pressure, 0.763 for those with improvement in reduced HDL-cholesterol, and 0.92 for those with improvement in abdominal obesity compared with those manifesting them at both time points. In conclusion, changes in metabolic syndrome and its components were significantly associated with the development of T2D. Improvement in MetS and its components attenuated the risk of diabetes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32047219</pmid><doi>10.1038/s41598-020-59203-z</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/163/2743/137 692/163/2743/2037 Adult Blood pressure Cholesterol Cohort analysis Cohort Studies Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - pathology Female Health risks High density lipoprotein Humanities and Social Sciences Humans Hypertension Hypertension - physiopathology Incidence Male Metabolic disorders Metabolic syndrome Metabolic Syndrome - complications Middle Aged multidisciplinary Obesity - physiopathology Prognosis Republic of Korea - epidemiology Risk Factors Science Science (multidisciplinary) Triglycerides Young Adult |
| title | Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study |
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