Alveolar Bone Protection by Targeting the SH3BP2‐SYK Axis in Osteoclasts

ABSTRACT Periodontitis is a bacterially induced chronic inflammatory condition of the oral cavity where tooth‐supporting tissues including alveolar bone are destructed. Previously, we have shown that the adaptor protein SH3‐domain binding protein 2 (SH3BP2) plays a critical role in inflammatory resp...

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Veröffentlicht in:	Journal of bone and mineral research 2020-02, Vol.35 (2), p.382-395
Hauptverfasser:	Kittaka, Mizuho, Yoshimoto, Tetsuya, Schlosser, Collin, Rottapel, Robert, Kajiya, Mikihito, Kurihara, Hidemi, Reichenberger, Ernst J, Ueki, Yasuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase (tartrate-resistant) Alveolar bone BONE LOSS Bone marrow Bone resorption Cytokines Gum disease Inflammation Macrophages Oral cavity Osteoclastogenesis OSTEOCLASTS Periodontal diseases PERIODONTITIS Protein-tyrosine kinase SH3BP2 Spleen SYK Syk protein Therapeutic applications TRANCE protein
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