Ibudilast attenuates peripheral inflammatory effects of methamphetamine in patients with methamphetamine use disorder

•Without Ibudilast, 30 mg methamphetamine infusion elevated sICAM-1, sVCAM-1, and cathepsin D in 60 min.•Without Ibudilast, 30 mg methamphetamine infusion elevated IL-6 in 360 min.•Ibudilast decreased methamphetamine-induced responses of sICAM-1, sVCAM-1, and cathepsin D compared to placebo. Preclin...

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Veröffentlicht in:	Drug and alcohol dependence 2020-01, Vol.206, p.107776-107776, Article 107776
Hauptverfasser:	Li, Michael J., Briones, Marisa S., Heinzerling, Keith G., Kalmin, Mariah M., Shoptaw, Steven J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amphetamine-Related Disorders - blood Amphetamine-Related Disorders - drug therapy Animals Anti-inflammatory Anti-inflammatory agents Attenuation Cathepsin D Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - adverse effects Clinical research Clinical trials Cross-Over Studies Cytokine Cytokines Female Humans Ibudilast Inflammation Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - blood Infusions, Intravenous Inpatient care Interleukin 6 Male Markers Methamphetamine Methamphetamine - administration & dosage Methamphetamine - adverse effects Middle Aged Patients Phosphodiesterase Phosphodiesterase inhibitor Phosphodiesterase inhibitors Phosphodiesterase Inhibitors - pharmacology Phosphodiesterase Inhibitors - therapeutic use Pyridines - pharmacology Pyridines - therapeutic use Tumor necrosis factor-α
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