Retooling Asymmetric Conjugate Additions for Sterically Demanding Substrates with an Iterative Data-Driven Approach

The development of catalytic enantioselective methods is routinely carried out using easily accessible and prototypical substrates. This approach to reaction development often yields asymmetric methods that perform poorly using substrates that are sterically or electronically dissimilar to those use...

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Veröffentlicht in:	ACS catalysis 2019-08, Vol.9 (8), p.7179-7187
Hauptverfasser:	Brethomé, Alexandre V, Paton, Robert S, Fletcher, Stephen P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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