Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients

Down syndrome (DS) is frequently comorbid with congenital heart disease and has recently been shown to reduce the sedative effect of benzodiazepine (BDZ)-class anesthesia but this effect in a clinical setting has not been studied. Therefore, this study compared midazolam sedation after heart surgery...

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Veröffentlicht in:	Scientific reports 2020-02, Vol.10 (1), p.2148-2148, Article 2148
Hauptverfasser:	Matsuishi, Yujiro, Sakuramoto, Hideaki, Hoshino, Haruhiko, Shimojo, Nobutake, Enomoto, Yuki, Mathis, Bryan J., Hiramatsu, Yuji, Inoue, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/3187 692/700/1720 Anesthesia Bayes Theorem Bayesian analysis Benzodiazepines Benzodiazepines - pharmacology Cardiovascular diseases Cardiovascular System Coronary artery disease Deep Sedation - methods Down syndrome Down Syndrome - metabolism Down Syndrome - physiopathology Down's syndrome Female Heart Defects, Congenital - metabolism Heart Defects, Congenital - surgery Heart diseases Heart surgery Humanities and Social Sciences Humans Hypnotics and Sedatives - pharmacology Infant Infant, Newborn Intensive Care Units, Pediatric Length of Stay Male Mathematical models Midazolam Midazolam - administration & dosage Midazolam - pharmacology multidisciplinary Muscle relaxants Patients Pediatrics Respiration, Artificial Retrospective Studies Science Science (multidisciplinary)
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