The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency

Maintaining the pluripotency of either embryonic stem (ES) cells or induced pluripotent stem (iPS) cells is a fundamental part of stem cell research. In this study, we reported that cordycepin promoted the expression of pluripotency markers in ES and iPS cells. ES cells treated with cordycepin demon...

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Veröffentlicht in:	Scientific reports 2020-02, Vol.10 (1), p.2187, Article 2187
Hauptverfasser:	Wang, Chie-Hong, Chang, Cheng-Hsuan, Lin, Tsung-Li, Fu, Ru-Huei, Huang, Yu-Chuen, Chen, Shih-Yin, Shyu, Woei-Cherng, Liu, Shih-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 631/532/2064/2158 631/532/2435 Animals Cell differentiation Cell Differentiation - genetics Cells, Cultured Ciliary neurotrophic factor Cordycepin Deoxyadenosines - metabolism Deoxyadenosines - pharmacology Embryo fibroblasts Embryoid Bodies - metabolism Embryonic Stem Cells - metabolism Epidermal growth factor Extracellular matrix Fibroblasts - metabolism Gene expression Humanities and Social Sciences Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Integrins - metabolism Interleukin 11 Interleukin 6 Janus kinase 2 Janus Kinase 2 - metabolism Mice multidisciplinary Oncostatin M Pluripotency Pluripotent Stem Cells - drug effects Pluripotent Stem Cells - metabolism Progenitor cells Science Science (multidisciplinary) Signal Transduction SOXB1 Transcription Factors - metabolism Stat3 protein STAT3 Transcription Factor - metabolism Stem cell transplantation Stem cells
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