Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma

Extrachromosomal circularization of DNA is an important genomic feature in cancer. However, the structure, composition and genome-wide frequency of extrachromosomal circular DNA have not yet been profiled extensively. Here, we combine genomic and transcriptomic approaches to describe the landscape o...

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Veröffentlicht in:	Nature genetics 2020-01, Vol.52 (1), p.29-34
Hauptverfasser:	Koche, Richard P., Rodriguez-Fos, Elias, Helmsauer, Konstantin, Burkert, Martin, MacArthur, Ian C., Maag, Jesper, Chamorro, Rocio, Munoz-Perez, Natalia, Puiggròs, Montserrat, Dorado Garcia, Heathcliff, Bei, Yi, Röefzaad, Claudia, Bardinet, Victor, Szymansky, Annabell, Winkler, Annika, Thole, Theresa, Timme, Natalie, Kasack, Katharina, Fuchs, Steffen, Klironomos, Filippos, Thiessen, Nina, Blanc, Eric, Schmelz, Karin, Künkele, Annette, Hundsdörfer, Patrick, Rosswog, Carolina, Theissen, Jessica, Beule, Dieter, Deubzer, Hedwig, Sauer, Sascha, Toedling, Joern, Fischer, Matthias, Hertwig, Falk, Schwarz, Roland F., Eggert, Angelika, Torrents, David, Schulte, Johannes H., Henssen, Anton G.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/212 692/699/67/1678 Agriculture Analysis Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carcinogenesis - pathology Children Chromosomes Circular DNA Circularity Deoxyribonucleic acid DNA DNA, Circular - genetics Extrachromosomal Inheritance - genetics Gene amplification Gene expression Gene Function Gene loci Gene Rearrangement Genetic aspects Genome, Human Genomes Genomics Haplotypes Human Genetics Humans Letter Lymphoma Mitochondrial DNA Neuroblastoma Neuroblastoma - genetics Neuroblastoma - pathology Oncogenes - genetics Pediatrics Recombination, Genetic Scientific equipment and supplies industry Sympathetic nervous system Tumor Cells, Cultured Tumors
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