The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets

Skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as systemic sclerosis, hypertrophic scars, and keloids. Effective anti-scarring therapeutics remain an unmet need, under...

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Veröffentlicht in:	Archives of Dermatological Research 2020-03, Vol.312 (2), p.81-92
Hauptverfasser:	Nguyen, Julie K., Austin, Evan, Huang, Alisen, Mamalis, Andrew, Jagdeo, Jared
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Cicatrix - metabolism Dermatology Dermis Extracellular matrix Fibrosis Fibrosis - metabolism Gene Expression Regulation Humans Interleukin 13 Interleukin 4 Interleukin-13 - genetics Interleukin-13 - metabolism Interleukin-4 - genetics Interleukin-4 - metabolism Lymphocytes T Medicine Medicine & Public Health Review Scars Skin - metabolism Skin diseases Systemic sclerosis Therapeutic applications Transforming growth factor-b Wound healing
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