Clinical implications of intratumor heterogeneity: challenges and opportunities
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through complex genetic, epigenetic, and protein modifications that drive phenotypic selection in response to environmen...
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| Veröffentlicht in: | Journal of molecular medicine (Berlin, Germany) Germany), 2020-02, Vol.98 (2), p.161-177 |
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| container_title | Journal of molecular medicine (Berlin, Germany) |
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| creator | Ramón y Cajal, Santiago Sesé, Marta Capdevila, Claudia Aasen, Trond De Mattos-Arruda, Leticia Diaz-Cano, Salvador J. Hernández-Losa, Javier Castellví, Josep |
| description | In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through complex genetic, epigenetic, and protein modifications that drive phenotypic selection in response to environmental pressures. Functionally, heterogeneity provides tumors with significant adaptability. This ranges from mutual beneficial cooperation between cells, which nurture features such as growth and metastasis, to the narrow escape and survival of clonal cell populations that have adapted to thrive under specific conditions such as hypoxia or chemotherapy. These dynamic intercellular interplays are guided by a Darwinian selection landscape between clonal tumor cell populations and the tumor microenvironment. Understanding the involved drivers and functional consequences of such tumor heterogeneity is challenging but also promises to provide novel insight needed to confront the problem of therapeutic resistance in tumors. |
| doi_str_mv | 10.1007/s00109-020-01874-2 |
| format | Article |
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| subjects | Adaptability Animals Biomedical and Life Sciences Biomedicine Cell survival Chemotherapy Epigenesis, Genetic Epigenetics Genetic Heterogeneity Human Genetics Humans Hypoxia Internal Medicine Metastases Molecular Medicine Neoplasms - genetics Neoplasms - therapy Phenotype Review Tumor Microenvironment Tumors |
| title | Clinical implications of intratumor heterogeneity: challenges and opportunities |
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