t-Darpp Activates IGF-1R Signaling to Regulate Glucose Metabolism in Trastuzumab-Resistant Breast Cancer Cells

Increased glycolysis and glucose dependence is a hallmark of malignancy that enables tumors to maximize cell proliferation. In HER2 cancers, an increase in glycolytic capacity is associated with trastuzumab resistance. IGF-1R activation and t-Darpp overexpression both confer trastuzumab resistance i...

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Veröffentlicht in:	Clinical cancer research 2018-03, Vol.24 (5), p.1216-1226
Hauptverfasser:	Lenz, Gal, Hamilton, Angelica, Geng, Shuhui, Hong, Teresa, Kalkum, Markus, Momand, Jamil, Kane, Susan E, Huss, Janice M
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Cell Line, Tumor Cell proliferation Datasets as Topic Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism Drug Resistance, Neoplasm Epidermal growth factor receptors ErbB protein ErbB Receptors - metabolism ErbB-2 protein Experimental design Female Gene Expression Regulation, Neoplastic Glucose Glucose metabolism Glycolysis Humans Immunotherapy Insulin-like growth factors Isoenzymes - metabolism Malignancy Metabolism Monoclonal antibodies mRNA Phenotypes Protein Multimerization Receptor, ErbB-2 - metabolism Receptors Receptors, Somatomedin - metabolism Signal Transduction Signaling siRNA Survival Survival Analysis Targeted cancer therapy Trastuzumab Trastuzumab - pharmacology Trastuzumab - therapeutic use Tumors
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