Requirement for epithelial p38α in KRAS-driven lung tumor progression

Malignant transformation entails important changes in the control of cell proliferation through the rewiring of selected signaling pathways. Cancer cells then become very dependent on the proper function of those pathways, and their inhibition offers therapeutic opportunities. Here we identify the s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-02, Vol.117 (5), p.2588-2596
Hauptverfasser:	Vitos-Faleato, Jessica, Real, Sebastián M., Gutierrez-Prat, Nuria, Villanueva, Alberto, Llonch, Elisabet, Drosten, Matthias, Barbacid, Mariano, Nebreda, Angel R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Alveoli Animal models Autocrine signalling Biological Sciences Cell growth Cell proliferation Cells (biology) Epithelial cells Genetic transformation K-Ras protein Kinases Lung cancer Organic chemistry Progenitor cells Rewiring Signal transduction Signaling Stem cells Tissue inhibitor of metalloproteinase 1 Tumor suppressor genes Tumors
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