Blood pressure in children with chronic kidney disease: lessons learned from the Chronic Kidney Disease in Children Cohort Study
Cardiovascular disease (CVD) is common among children and adolescents with chronic kidney disease (CKD) and end-stage kidney disease (ESRD). However, the early accrual of CVD risk factors in children with CKD has not been well studied. The Chronic Kidney Disease in Children (CKiD) Study, a multicent...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2020-07, Vol.35 (7), p.1203-1209 |
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| description | Cardiovascular disease (CVD) is common among children and adolescents with chronic kidney disease (CKD) and end-stage kidney disease (ESRD). However, the early accrual of CVD risk factors in children with CKD has not been well studied. The Chronic Kidney Disease in Children (CKiD) Study, a multicenter, prospective cohort study of children with mild-to-moderate CKD at study entry counts among its primary aims investigation of the drivers of CVD risk in this population. As the most prevalent CVD risk factor in children with CKD, blood pressure (BP) has been a major focus of investigation for the CKiD Study Group. Over the first 15 years of the study, landmark publications have better defined the prevalence of hypertension, the frequency with which it is under-recognized and thus undertreated, and the consequences of elevated BP in this cohort. The purpose of this review is to summarize the contributions made by the CKiD Study in advancing knowledge of BP in this high-risk population, and to highlight areas in need of further study. |
| doi_str_mv | 10.1007/s00467-019-04288-6 |
| format | Article |
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However, the early accrual of CVD risk factors in children with CKD has not been well studied. The Chronic Kidney Disease in Children (CKiD) Study, a multicenter, prospective cohort study of children with mild-to-moderate CKD at study entry counts among its primary aims investigation of the drivers of CVD risk in this population. As the most prevalent CVD risk factor in children with CKD, blood pressure (BP) has been a major focus of investigation for the CKiD Study Group. Over the first 15 years of the study, landmark publications have better defined the prevalence of hypertension, the frequency with which it is under-recognized and thus undertreated, and the consequences of elevated BP in this cohort. The purpose of this review is to summarize the contributions made by the CKiD Study in advancing knowledge of BP in this high-risk population, and to highlight areas in need of further study.</description><subject>Adolescents</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Child</subject><subject>Children</subject><subject>Chronic kidney failure</subject><subject>Cohort analysis</subject><subject>Complications and side effects</subject><subject>Educational Review</subject><subject>End-stage renal disease</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - epidemiology</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multicenter Studies as Topic</subject><subject>Nephrology</subject><subject>Pediatric research</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Risk Factors</subject><subject>Urology</subject><subject>What’s New in Chronic Kidney Disease</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kkuP0zAUhSMEYjoDf4AFsoSE2GSw49QPFkhDeIqRWADS7Cw3uWk8pHaxE0bd8dO5JZ1HUYWysOL7nXPt45tlTxg9ZZTKl4nSUsicMp3TslAqF_eyGSt5kTOtLu5nM6o5wxK7OMqOU7qklKq5Eg-zI864FpKxWfb7TR9CQ9YRUhojEOdJ3bm-ieDJlRs6_IvBu5r8cI2HDWlcApvgFelREHzC1UYPDWljWJGhA1LtBJ8nwdtJsDWuro2r0IU4kK_D2GweZQ9a2yd4vFtPsu_v332rPubnXz58qs7O81owOuR4UUkVU1bYuW0XDReyhEJyAKXEvKmtlqzVFuattFLrWpTFopB0rq0ABUzyk-z15LseFytoavBDtL1ZR7eycWOCdWa_4l1nluGXkRg1LxgavNgZxPBzhDSYlUs19L31EMZkCmxHGSbMEX32D3oZxujxekgJLRVnqryllrYH43wbsG-9NTVnoiiVVqXcts0PUEvwgIcMHlqH23v86QEevwZWrj4oeH5H0IHthy6FfhwcPu8-WExgHUNKEdqb8Bg124E000AaHEjzdyCNQNHTu7HfSK4nEAE-AQlLfgnxNqv_2P4Bsgfqyg</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Wilson, Amy C.</creator><creator>Flynn, Joseph T.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7232-7975</orcidid></search><sort><creationdate>20200701</creationdate><title>Blood pressure in children with chronic kidney disease: lessons learned from the Chronic Kidney Disease in Children Cohort Study</title><author>Wilson, Amy C. ; Flynn, Joseph T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-46770818a6a5afbd3674e273ee8865dca971f9ae5f7a799c642b27059a6e8e173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescents</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Child</topic><topic>Children</topic><topic>Chronic kidney failure</topic><topic>Cohort analysis</topic><topic>Complications and side effects</topic><topic>Educational Review</topic><topic>End-stage renal disease</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - epidemiology</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multicenter Studies as Topic</topic><topic>Nephrology</topic><topic>Pediatric research</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Risk Factors</topic><topic>Urology</topic><topic>What’s New in Chronic Kidney Disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, Amy C.</creatorcontrib><creatorcontrib>Flynn, Joseph T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, Amy C.</au><au>Flynn, Joseph T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood pressure in children with chronic kidney disease: lessons learned from the Chronic Kidney Disease in Children Cohort Study</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>35</volume><issue>7</issue><spage>1203</spage><epage>1209</epage><pages>1203-1209</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Cardiovascular disease (CVD) is common among children and adolescents with chronic kidney disease (CKD) and end-stage kidney disease (ESRD). However, the early accrual of CVD risk factors in children with CKD has not been well studied. The Chronic Kidney Disease in Children (CKiD) Study, a multicenter, prospective cohort study of children with mild-to-moderate CKD at study entry counts among its primary aims investigation of the drivers of CVD risk in this population. As the most prevalent CVD risk factor in children with CKD, blood pressure (BP) has been a major focus of investigation for the CKiD Study Group. Over the first 15 years of the study, landmark publications have better defined the prevalence of hypertension, the frequency with which it is under-recognized and thus undertreated, and the consequences of elevated BP in this cohort. The purpose of this review is to summarize the contributions made by the CKiD Study in advancing knowledge of BP in this high-risk population, and to highlight areas in need of further study.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31396711</pmid><doi>10.1007/s00467-019-04288-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7232-7975</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric nephrology (Berlin, West), 2020-07, Vol.35 (7), p.1203-1209 |
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| subjects | Adolescents Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive Agents - therapeutic use Blood pressure Blood Pressure - drug effects Cardiovascular diseases Cardiovascular Diseases - etiology Child Children Chronic kidney failure Cohort analysis Complications and side effects Educational Review End-stage renal disease Female Health aspects Health risk assessment Humans Hypertension - drug therapy Hypertension - epidemiology Kidney diseases Male Medicine Medicine & Public Health Multicenter Studies as Topic Nephrology Pediatric research Pediatrics Prospective Studies Renal Insufficiency, Chronic - complications Risk Factors Urology What’s New in Chronic Kidney Disease |
| title | Blood pressure in children with chronic kidney disease: lessons learned from the Chronic Kidney Disease in Children Cohort Study |
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