Comparison Between Integrated Genomic DNA/RNA Profiling and Fluorescence In Situ Hybridization in the Detection of MYC, BCL-2, and BCL-6 Gene Rearrangements in Large B-Cell Lymphomas

Abstract Objectives To compare fluorescence in situ hybridization (FISH) and a commercially available sequencing assay for comprehensive genomic profiling (CGP) to determine the best approach to identify gene rearrangements (GRs) in large B-cell lymphomas (LBCLs). Methods Comparison of standard-of-c...

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Veröffentlicht in:	American journal of clinical pathology 2020-02, Vol.153 (3), p.353-359
Hauptverfasser:	Cassidy, Daniel P, Chapman, Jennifer R, Lopez, Rafael, White, Kyle, Fan, Yao-Shan, Casas, Carmen, Severson, Eric A, Vega, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over B-cell lymphoma Bcl-2 protein BCL-6 gene Bcl-6 protein Comparative analysis Deoxyribonucleic acid Diagnosis DNA DNA fingerprinting DNA probes DNA sequencing Female Fluorescence in situ hybridization Gene Rearrangement Genetic aspects Genetic Profile Heavy chains Humans Immunoglobulins In Situ Hybridization, Fluorescence Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - pathology Lymphomas Male Medical prognosis Middle Aged Myc protein Nucleotide sequencing Original Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-6 - genetics Proto-Oncogene Proteins c-myc - genetics Ribonucleic acid RNA RNA sequencing
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