Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders
Absorption of glucose, via intestinal Na+/glucose cotransporter 1 (SGLT1), activates salt and water absorption and is an effective route for treating Escherichia coli (E. coli)-induced diarrhea. Activity and expression of SGLT1 is regulated by sensing of sugars and artificial/natural sweeteners by t...
Gespeichert in:
| Veröffentlicht in: | Journal of agricultural and food chemistry 2020-01, Vol.68 (2), p.441-450 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 450 |
|---|---|
| container_issue | 2 |
| container_start_page | 441 |
| container_title | Journal of agricultural and food chemistry |
| container_volume | 68 |
| creator | Moran, Andrew W Al-Rammahi, Miran A Daly, Kristian Grand, Emeline Ionescu, Catherine Bravo, David M Wall, Emma H Shirazi-Beechey, Soraya P |
| description | Absorption of glucose, via intestinal Na+/glucose cotransporter 1 (SGLT1), activates salt and water absorption and is an effective route for treating Escherichia coli (E. coli)-induced diarrhea. Activity and expression of SGLT1 is regulated by sensing of sugars and artificial/natural sweeteners by the intestinal sweet receptor T1R2-T1R3 expressed in enteroendocrine cells. Diarrhea, caused by the bacterial pathogen E. coli, is the most common post-weaning clinical feature in rabbits, leading to mortality. We demonstrate here that, in rabbits with experimentally E. coli-induced diarrhea, inclusion of a supplement containing stevia leaf extract (SL) in the feed decreases cumulative morbidity, improving clinical signs of disease (p < 0.01). We show that the rabbit intestine expresses T1R2-T1R3. Furthermore, intake of SL enhances activity and expression of SGLT1 and the intestinal capacity to absorb glucose (1.8-fold increase, p < 0.05). Thus, a natural plant extract sweetener can act as an effective feed additive for lessening the negative impact of enteric diseases in animals. |
| doi_str_mv | 10.1021/acs.jafc.9b04995 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7007240</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2315527244</sourcerecordid><originalsourceid>FETCH-LOGICAL-a433t-7730316282b2224ec80c7883d26e8de43363232829193fb87254b8aa55f872c53</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxSMEokvhzgn5WATZ-k-cOBekalm2K62KRMvZchyn6yqxU4-z0I_HN8PbXSo4cPJI895vZvyy7C3Bc4IpOVca5neq0_O6wUVd82fZjHCKc06IeJ7NcNLkgpfkJHsFcIcxFrzCL7MTRipWMixm2a-FdzANY7TeId8hha5UnILq0aW93eZrF40DGx_Q9Q9jUm0CWrqtctoAutDR7vY95Vq0_DkGA3DEfFNNYyPa2yFal3BX6sP5qp-0B4MWPgblYPQhJh5BZ9erzQ15_8hZD2Pwu0Rf-N42Stu-92AhbdJO2qQ5CRmsRp8t-NCaAK-zF53qwbw5vqfZ9y_Lm8Vlvvm6Wi8uNrkqGIt5VTHMSEkFbSilhdEC60oI1tLSiNYkTckoS-2a1KxrREV50QilOO9SrTk7zT4duOPUDKbVxqUjejkGO6jwIL2y8t-Os1t563eywriiBU6AsyMg-Psp_YscLGjT98oZP4GkjHBOk7RIUnyQ6uABgumexhAs98nLlLzcJy-PySfLu7_XezL8iToJPh4Ej1Y_hZQK_J_3G53JvTA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2315527244</pqid></control><display><type>article</type><title>Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Moran, Andrew W ; Al-Rammahi, Miran A ; Daly, Kristian ; Grand, Emeline ; Ionescu, Catherine ; Bravo, David M ; Wall, Emma H ; Shirazi-Beechey, Soraya P</creator><creatorcontrib>Moran, Andrew W ; Al-Rammahi, Miran A ; Daly, Kristian ; Grand, Emeline ; Ionescu, Catherine ; Bravo, David M ; Wall, Emma H ; Shirazi-Beechey, Soraya P</creatorcontrib><description>Absorption of glucose, via intestinal Na+/glucose cotransporter 1 (SGLT1), activates salt and water absorption and is an effective route for treating Escherichia coli (E. coli)-induced diarrhea. Activity and expression of SGLT1 is regulated by sensing of sugars and artificial/natural sweeteners by the intestinal sweet receptor T1R2-T1R3 expressed in enteroendocrine cells. Diarrhea, caused by the bacterial pathogen E. coli, is the most common post-weaning clinical feature in rabbits, leading to mortality. We demonstrate here that, in rabbits with experimentally E. coli-induced diarrhea, inclusion of a supplement containing stevia leaf extract (SL) in the feed decreases cumulative morbidity, improving clinical signs of disease (p < 0.01). We show that the rabbit intestine expresses T1R2-T1R3. Furthermore, intake of SL enhances activity and expression of SGLT1 and the intestinal capacity to absorb glucose (1.8-fold increase, p < 0.05). Thus, a natural plant extract sweetener can act as an effective feed additive for lessening the negative impact of enteric diseases in animals.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.9b04995</identifier><identifier>PMID: 31736308</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Diarrhea - drug therapy ; Diarrhea - microbiology ; Diarrhea - mortality ; Diarrhea - veterinary ; Enteroendocrine Cells - drug effects ; Enteroendocrine Cells - metabolism ; Escherichia coli - physiology ; Escherichia coli Infections - drug therapy ; Escherichia coli Infections - microbiology ; Escherichia coli Infections - mortality ; Escherichia coli Infections - veterinary ; Female ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - microbiology ; Male ; Non-Nutritive Sweeteners - administration & dosage ; Plant Extracts - administration & dosage ; Plant Leaves - chemistry ; Rabbits - metabolism ; Rabbits - microbiology ; Sodium-Glucose Transporter 1 - genetics ; Sodium-Glucose Transporter 1 - metabolism ; Stevia - chemistry</subject><ispartof>Journal of agricultural and food chemistry, 2020-01, Vol.68 (2), p.441-450</ispartof><rights>Copyright © 2019 American Chemical Society 2019 American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a433t-7730316282b2224ec80c7883d26e8de43363232829193fb87254b8aa55f872c53</citedby><cites>FETCH-LOGICAL-a433t-7730316282b2224ec80c7883d26e8de43363232829193fb87254b8aa55f872c53</cites><orcidid>0000-0003-0031-2154 ; 0000-0002-0165-7990 ; 0000-0001-9922-6357</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.9b04995$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.9b04995$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31736308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moran, Andrew W</creatorcontrib><creatorcontrib>Al-Rammahi, Miran A</creatorcontrib><creatorcontrib>Daly, Kristian</creatorcontrib><creatorcontrib>Grand, Emeline</creatorcontrib><creatorcontrib>Ionescu, Catherine</creatorcontrib><creatorcontrib>Bravo, David M</creatorcontrib><creatorcontrib>Wall, Emma H</creatorcontrib><creatorcontrib>Shirazi-Beechey, Soraya P</creatorcontrib><title>Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Absorption of glucose, via intestinal Na+/glucose cotransporter 1 (SGLT1), activates salt and water absorption and is an effective route for treating Escherichia coli (E. coli)-induced diarrhea. Activity and expression of SGLT1 is regulated by sensing of sugars and artificial/natural sweeteners by the intestinal sweet receptor T1R2-T1R3 expressed in enteroendocrine cells. Diarrhea, caused by the bacterial pathogen E. coli, is the most common post-weaning clinical feature in rabbits, leading to mortality. We demonstrate here that, in rabbits with experimentally E. coli-induced diarrhea, inclusion of a supplement containing stevia leaf extract (SL) in the feed decreases cumulative morbidity, improving clinical signs of disease (p < 0.01). We show that the rabbit intestine expresses T1R2-T1R3. Furthermore, intake of SL enhances activity and expression of SGLT1 and the intestinal capacity to absorb glucose (1.8-fold increase, p < 0.05). Thus, a natural plant extract sweetener can act as an effective feed additive for lessening the negative impact of enteric diseases in animals.</description><subject>Animals</subject><subject>Diarrhea - drug therapy</subject><subject>Diarrhea - microbiology</subject><subject>Diarrhea - mortality</subject><subject>Diarrhea - veterinary</subject><subject>Enteroendocrine Cells - drug effects</subject><subject>Enteroendocrine Cells - metabolism</subject><subject>Escherichia coli - physiology</subject><subject>Escherichia coli Infections - drug therapy</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Escherichia coli Infections - mortality</subject><subject>Escherichia coli Infections - veterinary</subject><subject>Female</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Male</subject><subject>Non-Nutritive Sweeteners - administration & dosage</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Leaves - chemistry</subject><subject>Rabbits - metabolism</subject><subject>Rabbits - microbiology</subject><subject>Sodium-Glucose Transporter 1 - genetics</subject><subject>Sodium-Glucose Transporter 1 - metabolism</subject><subject>Stevia - chemistry</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v1DAQxSMEokvhzgn5WATZ-k-cOBekalm2K62KRMvZchyn6yqxU4-z0I_HN8PbXSo4cPJI895vZvyy7C3Bc4IpOVca5neq0_O6wUVd82fZjHCKc06IeJ7NcNLkgpfkJHsFcIcxFrzCL7MTRipWMixm2a-FdzANY7TeId8hha5UnILq0aW93eZrF40DGx_Q9Q9jUm0CWrqtctoAutDR7vY95Vq0_DkGA3DEfFNNYyPa2yFal3BX6sP5qp-0B4MWPgblYPQhJh5BZ9erzQ15_8hZD2Pwu0Rf-N42Stu-92AhbdJO2qQ5CRmsRp8t-NCaAK-zF53qwbw5vqfZ9y_Lm8Vlvvm6Wi8uNrkqGIt5VTHMSEkFbSilhdEC60oI1tLSiNYkTckoS-2a1KxrREV50QilOO9SrTk7zT4duOPUDKbVxqUjejkGO6jwIL2y8t-Os1t563eywriiBU6AsyMg-Psp_YscLGjT98oZP4GkjHBOk7RIUnyQ6uABgumexhAs98nLlLzcJy-PySfLu7_XezL8iToJPh4Ej1Y_hZQK_J_3G53JvTA</recordid><startdate>20200115</startdate><enddate>20200115</enddate><creator>Moran, Andrew W</creator><creator>Al-Rammahi, Miran A</creator><creator>Daly, Kristian</creator><creator>Grand, Emeline</creator><creator>Ionescu, Catherine</creator><creator>Bravo, David M</creator><creator>Wall, Emma H</creator><creator>Shirazi-Beechey, Soraya P</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0031-2154</orcidid><orcidid>https://orcid.org/0000-0002-0165-7990</orcidid><orcidid>https://orcid.org/0000-0001-9922-6357</orcidid></search><sort><creationdate>20200115</creationdate><title>Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders</title><author>Moran, Andrew W ; Al-Rammahi, Miran A ; Daly, Kristian ; Grand, Emeline ; Ionescu, Catherine ; Bravo, David M ; Wall, Emma H ; Shirazi-Beechey, Soraya P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a433t-7730316282b2224ec80c7883d26e8de43363232829193fb87254b8aa55f872c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Diarrhea - drug therapy</topic><topic>Diarrhea - microbiology</topic><topic>Diarrhea - mortality</topic><topic>Diarrhea - veterinary</topic><topic>Enteroendocrine Cells - drug effects</topic><topic>Enteroendocrine Cells - metabolism</topic><topic>Escherichia coli - physiology</topic><topic>Escherichia coli Infections - drug therapy</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Escherichia coli Infections - mortality</topic><topic>Escherichia coli Infections - veterinary</topic><topic>Female</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Male</topic><topic>Non-Nutritive Sweeteners - administration & dosage</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Leaves - chemistry</topic><topic>Rabbits - metabolism</topic><topic>Rabbits - microbiology</topic><topic>Sodium-Glucose Transporter 1 - genetics</topic><topic>Sodium-Glucose Transporter 1 - metabolism</topic><topic>Stevia - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moran, Andrew W</creatorcontrib><creatorcontrib>Al-Rammahi, Miran A</creatorcontrib><creatorcontrib>Daly, Kristian</creatorcontrib><creatorcontrib>Grand, Emeline</creatorcontrib><creatorcontrib>Ionescu, Catherine</creatorcontrib><creatorcontrib>Bravo, David M</creatorcontrib><creatorcontrib>Wall, Emma H</creatorcontrib><creatorcontrib>Shirazi-Beechey, Soraya P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moran, Andrew W</au><au>Al-Rammahi, Miran A</au><au>Daly, Kristian</au><au>Grand, Emeline</au><au>Ionescu, Catherine</au><au>Bravo, David M</au><au>Wall, Emma H</au><au>Shirazi-Beechey, Soraya P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2020-01-15</date><risdate>2020</risdate><volume>68</volume><issue>2</issue><spage>441</spage><epage>450</epage><pages>441-450</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>Absorption of glucose, via intestinal Na+/glucose cotransporter 1 (SGLT1), activates salt and water absorption and is an effective route for treating Escherichia coli (E. coli)-induced diarrhea. Activity and expression of SGLT1 is regulated by sensing of sugars and artificial/natural sweeteners by the intestinal sweet receptor T1R2-T1R3 expressed in enteroendocrine cells. Diarrhea, caused by the bacterial pathogen E. coli, is the most common post-weaning clinical feature in rabbits, leading to mortality. We demonstrate here that, in rabbits with experimentally E. coli-induced diarrhea, inclusion of a supplement containing stevia leaf extract (SL) in the feed decreases cumulative morbidity, improving clinical signs of disease (p < 0.01). We show that the rabbit intestine expresses T1R2-T1R3. Furthermore, intake of SL enhances activity and expression of SGLT1 and the intestinal capacity to absorb glucose (1.8-fold increase, p < 0.05). Thus, a natural plant extract sweetener can act as an effective feed additive for lessening the negative impact of enteric diseases in animals.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>31736308</pmid><doi>10.1021/acs.jafc.9b04995</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0031-2154</orcidid><orcidid>https://orcid.org/0000-0002-0165-7990</orcidid><orcidid>https://orcid.org/0000-0001-9922-6357</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8561 |
| ispartof | Journal of agricultural and food chemistry, 2020-01, Vol.68 (2), p.441-450 |
| issn | 0021-8561 1520-5118 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7007240 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Diarrhea - drug therapy Diarrhea - microbiology Diarrhea - mortality Diarrhea - veterinary Enteroendocrine Cells - drug effects Enteroendocrine Cells - metabolism Escherichia coli - physiology Escherichia coli Infections - drug therapy Escherichia coli Infections - microbiology Escherichia coli Infections - mortality Escherichia coli Infections - veterinary Female Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Male Non-Nutritive Sweeteners - administration & dosage Plant Extracts - administration & dosage Plant Leaves - chemistry Rabbits - metabolism Rabbits - microbiology Sodium-Glucose Transporter 1 - genetics Sodium-Glucose Transporter 1 - metabolism Stevia - chemistry |
| title | Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T19%3A38%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Consumption%20of%20a%20Natural%20High-Intensity%20Sweetener%20Enhances%20Activity%20and%20Expression%20of%20Rabbit%20Intestinal%20Na+/Glucose%20Cotransporter%201%20(SGLT1)%20and%20Improves%20Colibacillosis-Induced%20Enteric%20Disorders&rft.jtitle=Journal%20of%20agricultural%20and%20food%20chemistry&rft.au=Moran,%20Andrew%20W&rft.date=2020-01-15&rft.volume=68&rft.issue=2&rft.spage=441&rft.epage=450&rft.pages=441-450&rft.issn=0021-8561&rft.eissn=1520-5118&rft_id=info:doi/10.1021/acs.jafc.9b04995&rft_dat=%3Cproquest_pubme%3E2315527244%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2315527244&rft_id=info:pmid/31736308&rfr_iscdi=true |