Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery

Background The mechanisms that govern the egress of mature thymocytes from the human thymus to the periphery remain understudied yet are of utmost importance to the field of basic immunology, as well as T-cell reconstitution in various immunodeficiencies. We examined the expression and function of s...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2016-08, Vol.138 (2), p.551-557.e8
Hauptverfasser:	Resop, Rachel S., PhD, Douaisi, Marc, PhD, Craft, Joshua, BS, Jachimowski, Loes C.M., PhD, Blom, Bianca, PhD, Uittenbogaart, Christel H., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Biomarkers Cell Movement - immunology Chemotaxis - immunology Chlorophyll Flow cytometry Gene Expression Human subjects Humans Immunophenotyping Kinases Lymphocytes Lysophospholipids - metabolism Phenotype Proteins R&D Receptors, Lysosphingolipid - metabolism Research & development Signal Transduction Software Sphingosine - analogs & derivatives Sphingosine - metabolism Stem cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymocytes - immunology Thymocytes - metabolism Thymus Gland - immunology Thymus Gland - metabolism
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