Foretinib Inhibits Cancer Stemness and Gastric Cancer Cell Proliferation by Decreasing CD44 and c-MET Signaling

CD44 isoforms are highly expressed in cancer stem cells, initiating tumor growth and sustaining tumor self-renewal. Among these isoforms, CD44 variant 9 (CD44v9) is overexpressed in chronic inflammation-induced cancer. CD44 and the mesenchymal-to-epithelial transition (MET) receptor tyrosine kinase...

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Veröffentlicht in:	OncoTargets and therapy 2020-02, Vol.13, p.1027-1035
Hauptverfasser:	Sohn, Sung-Hwa, Kim, Bohyun, Sul, Hee Jung, Choi, Bo Youn, Kim, Hyeong Su, Zang, Dae Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Apoptosis Cancer Cancer research Gene expression Genes Inflammation Original Research Phenols (Class of compounds) Polymerase chain reaction Stem cells Stomach cancer Transcription (Genetics) Tumors Tyrosine Vascular endothelial growth factor
Online-Zugang:	Volltext
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