Selection of 2′-Deoxy-2′-Fluoroarabino Nucleic Acid (FANA) Aptamers That Bind HIV‑1 Integrase with Picomolar Affinity

Systematic Evolution of Ligands by Exponential Enrichment (SELEX) is the iterative process by which nucleic acids that can bind with high affinity and specificity (termed aptamers) to specific protein targets are selected. Using a SELEX protocol adapted for Xeno-Nucleic Acid (XNA) as a suitable subs...

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Veröffentlicht in:	ACS chemical biology 2019-10, Vol.14 (10), p.2166-2175, Article acschembio.9b00237
Hauptverfasser:	Rose, Kevin M, Alves Ferreira-Bravo, Irani, Li, Min, Craigie, Robert, Ditzler, Mark A, Holliger, Philipp, DeStefano, Jeffrey J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers, Nucleotide - chemistry Arabinonucleotides - chemistry Base Sequence HIV Integrase - chemistry HIV-1 - enzymology RNA - chemistry SELEX Aptamer Technique Sequence Alignment
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