Integrative Network Analysis of Differentially Methylated and Expressed Genes for Biomarker Identification in Leukemia

Genome-wide DNA methylation and gene expression are commonly altered in pediatric acute lymphoblastic leukemia (PALL). Integrated network analysis of cytosine methylation and expression datasets has the potential to provide deeper insights into the complex disease states and their causes than indivi...

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Veröffentlicht in:	Scientific reports 2020-02, Vol.10 (1), p.2123-2123, Article 2123
Hauptverfasser:	Sanchez, Robersy, Mackenzie, Sally A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 45 45/23 631/67/69 692/53/2421 Acute lymphoblastic leukemia AKT protein Biomarkers Biomarkers, Tumor - genetics Bisulfite Cancer Computational Biology Cytosine Databases, Genetic DNA methylation DNA Methylation - genetics Epidermal growth factor receptors Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Gene Regulatory Networks - genetics Genomes Humanities and Social Sciences Humans Learning algorithms Leukemia Leukemia - genetics Lymphatic leukemia Machine learning multidisciplinary Notch1 protein Pediatrics Phosphatidylinositol 3-Kinases - genetics Prognosis Protein Interaction Maps - genetics Proto-Oncogene Proteins c-akt - genetics Rac1 protein Rap1 protein Science Science (multidisciplinary) Signal transduction Signal Transduction - genetics Statistical analysis Stochasticity
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