Synchronous versus sequential chemo-radiotherapy in patients with early stage breast cancer (SECRAB): A randomised, phase III, trial

•SECRAB is the largest chemo-radiotherapy trial to date in early breast cancer.•SECRAB showed a positive therapeutic benefit of using adjuvant synchronous chemo-radiotherapy.•Synchronous chemo-radiotherapy should be used for ≤ 3 week radiotherapy schedules.•SECRAB results are applicable to patients...

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Veröffentlicht in:	Radiotherapy and oncology 2020-01, Vol.142, p.52-61
Hauptverfasser:	Fernando, Indrajit N., Bowden, Sarah J., Herring, Kathryn, Brookes, Cassandra L., Ahmed, Ikhlaaq, Marshall, Andrea, Grieve, Robert, Churn, Mark, Spooner, David, Latief, Talaat N., Agrawal, Rajiv K., Brunt, Adrian M., Stevens, Andrea, Goodman, Andrew, Canney, Peter, Bishop, Jill, Ritchie, Diana, Dunn, Janet, Poole, Christopher J., Rea, Daniel W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anthracyclines - administration & dosage Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Breast cancer Breast Neoplasms - pathology Chemo-radiotherapy Chemoradiotherapy, Adjuvant Cisplatin - administration & dosage Clinical trial Disease-Free Survival Female Fluorouracil - administration & dosage Humans Methotrexate - administration & dosage Middle Aged Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - radiotherapy Neoplasm Staging Prospective Studies Radiotherapy Treatment Outcome Young Adult
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