Lipid droplets: platforms with multiple functions in cancer hallmarks
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism, membrane trafficking, and the production of inflammatory mediators. Lipid droplet biogenesis is a regulated process, and accumulation of these organelles...
Gespeichert in:
| Veröffentlicht in: | Cell death & disease 2020-02, Vol.11 (2), p.105, Article 105 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 2 |
| container_start_page | 105 |
| container_title | Cell death & disease |
| container_volume | 11 |
| creator | Cruz, André L. S. Barreto, Ester de A. Fazolini, Narayana P. B. Viola, João P. B. Bozza, Patricia T. |
| description | Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism, membrane trafficking, and the production of inflammatory mediators. Lipid droplet biogenesis is a regulated process, and accumulation of these organelles within leukocytes, epithelial cells, hepatocytes, and other nonadipocyte cells is a frequently observed phenotype in several physiologic or pathogenic situations and is thoroughly described during inflammatory conditions. Moreover, in recent years, several studies have described an increase in intracellular lipid accumulation in different neoplastic processes, although it is not clear whether lipid droplet accumulation is directly involved in the establishment of these different types of malignancies. This review discusses current evidence related to the biogenesis, composition and functions of lipid droplets related to the hallmarks of cancer: inflammation, cell metabolism, increased proliferation, escape from cell death, and hypoxia. Moreover, the potential of lipid droplets as markers of disease and targets for novel anti-inflammatory and antineoplastic therapies will be discussed. |
| doi_str_mv | 10.1038/s41419-020-2297-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7005265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2352042947</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-d4dc839952f5ea42ab011f335186bd7f1b0e89581aa0c823ccf3fcdb8923ddb53</originalsourceid><addsrcrecordid>eNp1kUtLxDAUhYMoKqM_wI0U3Lip5tVp6kKQwRcMuNF1SPNwomlSk1bx35txfIN3k8D57rn3cgDYQ_AIQcKOE0UUNSXEsMS4qUuyBrYxpKikjDXrP_5bYDelB5iLEIir6SbYIhjmFoq2wfnc9lYVKobe6SGdFL0TgwmxS8WLHRZFN7rBZqkwo5eDDT4V1hdSeKljsRDOdSI-ph2wYYRLevfjnYC7i_Pb2VU5v7m8np3NS0lrOJSKKslI01TYVFpQLFqIkCGkQmzaqtqgFmrWVAwJASXDREpDjFQtazBRqq3IBJyufPux7bSS2g9RON5Hm9d45UFY_lvxdsHvwzOvIazwdGlw-GEQw9Oo08A7m6R2TngdxsQxyRjBJNcEHPxBH8IYfT7vnYIUN7TOFFpRMoaUojZfyyDIlznxVU4858SXOfGl8_7PK746PlPJAF4BKUv-Xsfv0f-7vgFRG55i</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2352042947</pqid></control><display><type>article</type><title>Lipid droplets: platforms with multiple functions in cancer hallmarks</title><source>Springer Open Access</source><source>MEDLINE</source><source>Nature Free</source><source>PubMed Central (PMC)</source><source>DOAJ Directory of Open Access Journals</source><source>EZB Electronic Journals Library</source><creator>Cruz, André L. S. ; Barreto, Ester de A. ; Fazolini, Narayana P. B. ; Viola, João P. B. ; Bozza, Patricia T.</creator><creatorcontrib>Cruz, André L. S. ; Barreto, Ester de A. ; Fazolini, Narayana P. B. ; Viola, João P. B. ; Bozza, Patricia T.</creatorcontrib><description>Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism, membrane trafficking, and the production of inflammatory mediators. Lipid droplet biogenesis is a regulated process, and accumulation of these organelles within leukocytes, epithelial cells, hepatocytes, and other nonadipocyte cells is a frequently observed phenotype in several physiologic or pathogenic situations and is thoroughly described during inflammatory conditions. Moreover, in recent years, several studies have described an increase in intracellular lipid accumulation in different neoplastic processes, although it is not clear whether lipid droplet accumulation is directly involved in the establishment of these different types of malignancies. This review discusses current evidence related to the biogenesis, composition and functions of lipid droplets related to the hallmarks of cancer: inflammation, cell metabolism, increased proliferation, escape from cell death, and hypoxia. Moreover, the potential of lipid droplets as markers of disease and targets for novel anti-inflammatory and antineoplastic therapies will be discussed.</description><identifier>ISSN: 2041-4889</identifier><identifier>EISSN: 2041-4889</identifier><identifier>DOI: 10.1038/s41419-020-2297-3</identifier><identifier>PMID: 32029741</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/45/287 ; 631/67/2327 ; 692/420/256 ; Animals ; Antibodies ; Biochemistry ; Biomedical and Life Sciences ; Biosynthesis ; Cell Biology ; Cell Culture ; Cell Death ; Cell Proliferation ; Cell Transformation, Neoplastic - metabolism ; Cell Transformation, Neoplastic - pathology ; Energy Metabolism ; Epithelial cells ; Hepatocytes ; Humans ; Hypoxia ; Immunology ; Inflammation ; Inflammation Mediators - metabolism ; Leukocytes ; Life Sciences ; Lipid bodies ; Lipid Droplets - metabolism ; Lipid Droplets - pathology ; Lipid metabolism ; Lipids ; Membrane trafficking ; Metabolism ; Neoplasms - metabolism ; Neoplasms - pathology ; Neoplastic Stem Cells - metabolism ; Neoplastic Stem Cells - pathology ; Organelles ; Phenotypes ; Review ; Review Article ; Signal Transduction ; Tumor Hypoxia ; Tumor Microenvironment</subject><ispartof>Cell death & disease, 2020-02, Vol.11 (2), p.105, Article 105</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-d4dc839952f5ea42ab011f335186bd7f1b0e89581aa0c823ccf3fcdb8923ddb53</citedby><cites>FETCH-LOGICAL-c470t-d4dc839952f5ea42ab011f335186bd7f1b0e89581aa0c823ccf3fcdb8923ddb53</cites><orcidid>0000-0002-1982-5841 ; 0000-0002-1360-6357 ; 0000-0001-8349-9529 ; 0000-0002-0698-3146</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005265/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005265/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32029741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruz, André L. S.</creatorcontrib><creatorcontrib>Barreto, Ester de A.</creatorcontrib><creatorcontrib>Fazolini, Narayana P. B.</creatorcontrib><creatorcontrib>Viola, João P. B.</creatorcontrib><creatorcontrib>Bozza, Patricia T.</creatorcontrib><title>Lipid droplets: platforms with multiple functions in cancer hallmarks</title><title>Cell death & disease</title><addtitle>Cell Death Dis</addtitle><addtitle>Cell Death Dis</addtitle><description>Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism, membrane trafficking, and the production of inflammatory mediators. Lipid droplet biogenesis is a regulated process, and accumulation of these organelles within leukocytes, epithelial cells, hepatocytes, and other nonadipocyte cells is a frequently observed phenotype in several physiologic or pathogenic situations and is thoroughly described during inflammatory conditions. Moreover, in recent years, several studies have described an increase in intracellular lipid accumulation in different neoplastic processes, although it is not clear whether lipid droplet accumulation is directly involved in the establishment of these different types of malignancies. This review discusses current evidence related to the biogenesis, composition and functions of lipid droplets related to the hallmarks of cancer: inflammation, cell metabolism, increased proliferation, escape from cell death, and hypoxia. Moreover, the potential of lipid droplets as markers of disease and targets for novel anti-inflammatory and antineoplastic therapies will be discussed.</description><subject>631/45/287</subject><subject>631/67/2327</subject><subject>692/420/256</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biosynthesis</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>Cell Death</subject><subject>Cell Proliferation</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Energy Metabolism</subject><subject>Epithelial cells</subject><subject>Hepatocytes</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Leukocytes</subject><subject>Life Sciences</subject><subject>Lipid bodies</subject><subject>Lipid Droplets - metabolism</subject><subject>Lipid Droplets - pathology</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Membrane trafficking</subject><subject>Metabolism</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Organelles</subject><subject>Phenotypes</subject><subject>Review</subject><subject>Review Article</subject><subject>Signal Transduction</subject><subject>Tumor Hypoxia</subject><subject>Tumor Microenvironment</subject><issn>2041-4889</issn><issn>2041-4889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtLxDAUhYMoKqM_wI0U3Lip5tVp6kKQwRcMuNF1SPNwomlSk1bx35txfIN3k8D57rn3cgDYQ_AIQcKOE0UUNSXEsMS4qUuyBrYxpKikjDXrP_5bYDelB5iLEIir6SbYIhjmFoq2wfnc9lYVKobe6SGdFL0TgwmxS8WLHRZFN7rBZqkwo5eDDT4V1hdSeKljsRDOdSI-ph2wYYRLevfjnYC7i_Pb2VU5v7m8np3NS0lrOJSKKslI01TYVFpQLFqIkCGkQmzaqtqgFmrWVAwJASXDREpDjFQtazBRqq3IBJyufPux7bSS2g9RON5Hm9d45UFY_lvxdsHvwzOvIazwdGlw-GEQw9Oo08A7m6R2TngdxsQxyRjBJNcEHPxBH8IYfT7vnYIUN7TOFFpRMoaUojZfyyDIlznxVU4858SXOfGl8_7PK746PlPJAF4BKUv-Xsfv0f-7vgFRG55i</recordid><startdate>20200206</startdate><enddate>20200206</enddate><creator>Cruz, André L. S.</creator><creator>Barreto, Ester de A.</creator><creator>Fazolini, Narayana P. B.</creator><creator>Viola, João P. B.</creator><creator>Bozza, Patricia T.</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1982-5841</orcidid><orcidid>https://orcid.org/0000-0002-1360-6357</orcidid><orcidid>https://orcid.org/0000-0001-8349-9529</orcidid><orcidid>https://orcid.org/0000-0002-0698-3146</orcidid></search><sort><creationdate>20200206</creationdate><title>Lipid droplets: platforms with multiple functions in cancer hallmarks</title><author>Cruz, André L. S. ; Barreto, Ester de A. ; Fazolini, Narayana P. B. ; Viola, João P. B. ; Bozza, Patricia T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-d4dc839952f5ea42ab011f335186bd7f1b0e89581aa0c823ccf3fcdb8923ddb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/45/287</topic><topic>631/67/2327</topic><topic>692/420/256</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biosynthesis</topic><topic>Cell Biology</topic><topic>Cell Culture</topic><topic>Cell Death</topic><topic>Cell Proliferation</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Energy Metabolism</topic><topic>Epithelial cells</topic><topic>Hepatocytes</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Leukocytes</topic><topic>Life Sciences</topic><topic>Lipid bodies</topic><topic>Lipid Droplets - metabolism</topic><topic>Lipid Droplets - pathology</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Membrane trafficking</topic><topic>Metabolism</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplastic Stem Cells - metabolism</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Organelles</topic><topic>Phenotypes</topic><topic>Review</topic><topic>Review Article</topic><topic>Signal Transduction</topic><topic>Tumor Hypoxia</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruz, André L. S.</creatorcontrib><creatorcontrib>Barreto, Ester de A.</creatorcontrib><creatorcontrib>Fazolini, Narayana P. B.</creatorcontrib><creatorcontrib>Viola, João P. B.</creatorcontrib><creatorcontrib>Bozza, Patricia T.</creatorcontrib><collection>Springer Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell death & disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cruz, André L. S.</au><au>Barreto, Ester de A.</au><au>Fazolini, Narayana P. B.</au><au>Viola, João P. B.</au><au>Bozza, Patricia T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid droplets: platforms with multiple functions in cancer hallmarks</atitle><jtitle>Cell death & disease</jtitle><stitle>Cell Death Dis</stitle><addtitle>Cell Death Dis</addtitle><date>2020-02-06</date><risdate>2020</risdate><volume>11</volume><issue>2</issue><spage>105</spage><pages>105-</pages><artnum>105</artnum><issn>2041-4889</issn><eissn>2041-4889</eissn><abstract>Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism, membrane trafficking, and the production of inflammatory mediators. Lipid droplet biogenesis is a regulated process, and accumulation of these organelles within leukocytes, epithelial cells, hepatocytes, and other nonadipocyte cells is a frequently observed phenotype in several physiologic or pathogenic situations and is thoroughly described during inflammatory conditions. Moreover, in recent years, several studies have described an increase in intracellular lipid accumulation in different neoplastic processes, although it is not clear whether lipid droplet accumulation is directly involved in the establishment of these different types of malignancies. This review discusses current evidence related to the biogenesis, composition and functions of lipid droplets related to the hallmarks of cancer: inflammation, cell metabolism, increased proliferation, escape from cell death, and hypoxia. Moreover, the potential of lipid droplets as markers of disease and targets for novel anti-inflammatory and antineoplastic therapies will be discussed.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32029741</pmid><doi>10.1038/s41419-020-2297-3</doi><orcidid>https://orcid.org/0000-0002-1982-5841</orcidid><orcidid>https://orcid.org/0000-0002-1360-6357</orcidid><orcidid>https://orcid.org/0000-0001-8349-9529</orcidid><orcidid>https://orcid.org/0000-0002-0698-3146</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2041-4889 |
| ispartof | Cell death & disease, 2020-02, Vol.11 (2), p.105, Article 105 |
| issn | 2041-4889 2041-4889 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7005265 |
| source | Springer Open Access; MEDLINE; Nature Free; PubMed Central (PMC); DOAJ Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | 631/45/287 631/67/2327 692/420/256 Animals Antibodies Biochemistry Biomedical and Life Sciences Biosynthesis Cell Biology Cell Culture Cell Death Cell Proliferation Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Energy Metabolism Epithelial cells Hepatocytes Humans Hypoxia Immunology Inflammation Inflammation Mediators - metabolism Leukocytes Life Sciences Lipid bodies Lipid Droplets - metabolism Lipid Droplets - pathology Lipid metabolism Lipids Membrane trafficking Metabolism Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Organelles Phenotypes Review Review Article Signal Transduction Tumor Hypoxia Tumor Microenvironment |
| title | Lipid droplets: platforms with multiple functions in cancer hallmarks |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T16%3A36%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lipid%20droplets:%20platforms%20with%20multiple%20functions%20in%20cancer%20hallmarks&rft.jtitle=Cell%20death%20&%20disease&rft.au=Cruz,%20Andr%C3%A9%20L.%20S.&rft.date=2020-02-06&rft.volume=11&rft.issue=2&rft.spage=105&rft.pages=105-&rft.artnum=105&rft.issn=2041-4889&rft.eissn=2041-4889&rft_id=info:doi/10.1038/s41419-020-2297-3&rft_dat=%3Cproquest_pubme%3E2352042947%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2352042947&rft_id=info:pmid/32029741&rfr_iscdi=true |