Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats
While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mechanisms remain uncharacterized. We developed a combined mechano-electrical acupuncture devi...
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| Veröffentlicht in: | The journal of physiological sciences 2020-02, Vol.70 (1), p.14-14, Article 14 |
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| container_title | The journal of physiological sciences |
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| creator | Shin, Joo Hyun Fan, Yu Kim, Do-Hee Jang, Han Byeol Chang, Suchan Ryu, Yeonhee Bae, Jong Han Lee, Sanghag Lee, Bong Hyo Steffensen, Scott C Yang, Chae Ha Kim, Hee Young |
| description | While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mechanisms remain uncharacterized. We developed a combined mechano-electrical acupuncture device (MEA) and examined the effects of acupuncture at Neuro-Sps on systolic blood pressure (BP) in a rat model of immobilization-induced hypertension (IMH) and the mediation of endogenous opioid systems in its effect. Cutaneous neurogenic spots were found mostly in the forelimb. Electrical and mechanical acupuncture of Neuro-Sps increased 22-kHz ultrasonic vocalizations (USVs), c-Fos expression and cell excitability in the midbrain and synergistically alleviated the development of hypertension following immobilization stress, which was prevented by administration of the opioid antagonist naloxone into the rostral ventrolateral medulla (rVLM). These findings suggest that mechanical and electrical stimulation at Neuro-Sps suppresses the development of hypertension via mediation of the endogenous opioid system. |
| doi_str_mv | 10.1186/s12576-020-00735-4 |
| format | Article |
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We developed a combined mechano-electrical acupuncture device (MEA) and examined the effects of acupuncture at Neuro-Sps on systolic blood pressure (BP) in a rat model of immobilization-induced hypertension (IMH) and the mediation of endogenous opioid systems in its effect. Cutaneous neurogenic spots were found mostly in the forelimb. Electrical and mechanical acupuncture of Neuro-Sps increased 22-kHz ultrasonic vocalizations (USVs), c-Fos expression and cell excitability in the midbrain and synergistically alleviated the development of hypertension following immobilization stress, which was prevented by administration of the opioid antagonist naloxone into the rostral ventrolateral medulla (rVLM). These findings suggest that mechanical and electrical stimulation at Neuro-Sps suppresses the development of hypertension via mediation of the endogenous opioid system.</description><identifier>ISSN: 1880-6546</identifier><identifier>EISSN: 1880-6562</identifier><identifier>DOI: 10.1186/s12576-020-00735-4</identifier><identifier>PMID: 32039692</identifier><language>eng</language><publisher>Japan: Springer</publisher><subject>Acupuncture ; Blood pressure ; c-Fos protein ; Electrical stimuli ; Electroacupuncture ; Electrodes ; Excitability ; Hypertension ; Immobilization ; Inflammation ; Laboratory animals ; Mediation ; Medulla oblongata ; Mesencephalon ; Naloxone ; Narcotics ; Opioids ; Original Paper ; Printed circuit boards</subject><ispartof>The journal of physiological sciences, 2020-02, Vol.70 (1), p.14-14, Article 14</ispartof><rights>COPYRIGHT 2020 Springer</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-d59489a9aa931caa778f037d63aac6850ee5f75129750d3fb2285a78d48730913</citedby><cites>FETCH-LOGICAL-c559t-d59489a9aa931caa778f037d63aac6850ee5f75129750d3fb2285a78d48730913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005077/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005077/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32039692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Joo Hyun</creatorcontrib><creatorcontrib>Fan, Yu</creatorcontrib><creatorcontrib>Kim, Do-Hee</creatorcontrib><creatorcontrib>Jang, Han Byeol</creatorcontrib><creatorcontrib>Chang, Suchan</creatorcontrib><creatorcontrib>Ryu, Yeonhee</creatorcontrib><creatorcontrib>Bae, Jong Han</creatorcontrib><creatorcontrib>Lee, Sanghag</creatorcontrib><creatorcontrib>Lee, Bong Hyo</creatorcontrib><creatorcontrib>Steffensen, Scott C</creatorcontrib><creatorcontrib>Yang, Chae Ha</creatorcontrib><creatorcontrib>Kim, Hee Young</creatorcontrib><title>Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats</title><title>The journal of physiological sciences</title><addtitle>J Physiol Sci</addtitle><description>While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mechanisms remain uncharacterized. 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These findings suggest that mechanical and electrical stimulation at Neuro-Sps suppresses the development of hypertension via mediation of the endogenous opioid system.</description><subject>Acupuncture</subject><subject>Blood pressure</subject><subject>c-Fos protein</subject><subject>Electrical stimuli</subject><subject>Electroacupuncture</subject><subject>Electrodes</subject><subject>Excitability</subject><subject>Hypertension</subject><subject>Immobilization</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>Mediation</subject><subject>Medulla oblongata</subject><subject>Mesencephalon</subject><subject>Naloxone</subject><subject>Narcotics</subject><subject>Opioids</subject><subject>Original Paper</subject><subject>Printed circuit boards</subject><issn>1880-6546</issn><issn>1880-6562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkktv1DAUhSMEoqXwB1igSGzYpFzbcexskKqKl1QJFrC2bu2bGVeJHewEqRI_Hk-nDBSNvPDrO8fXV6eqXjI4Z0x3bzPjUnUNcGgAlJBN-6g6ZVpD08mOPz6s2-6kepbzDUDb9Vw_rU4EB9GX9Wn16yv6RK6eyG4xeItjjcHVNJJd0n5r13kNdlkT1XGoA60pbqigdZ7jkmsf3Gop13H20btmIudxKY55nedEOfsYdrrt7UxpoXC396FOuOTn1ZMBx0wv7uez6vuH998uPzVXXz5-vry4aqyU_dI42be6xx6xF8wiKqUHEMp1AtF2WgKRHJRkvFcSnBiuOdcSlXatVgJ6Js6qd3vfeb0u9VkKS8LRzMlPmG5NRG8e3gS_NZv40ygACUoVgzf3Bin-WCkvZvLZ0jhioLhmw4UUwECz3Vuv_0Nv4ppC-Z7hslUgS53iL7XBkYwPQyzv2p2puVCdFAUFXajmCFWaT6XIGGjw5fgBf36EL8PR5O1RAd8LbIo5JxoOPWFgdhkz-4yZkjFzlzHTFtGrf7t5kPwJlfgN5MnNbw</recordid><startdate>20200206</startdate><enddate>20200206</enddate><creator>Shin, Joo Hyun</creator><creator>Fan, Yu</creator><creator>Kim, Do-Hee</creator><creator>Jang, Han Byeol</creator><creator>Chang, Suchan</creator><creator>Ryu, Yeonhee</creator><creator>Bae, Jong Han</creator><creator>Lee, Sanghag</creator><creator>Lee, Bong Hyo</creator><creator>Steffensen, Scott C</creator><creator>Yang, Chae Ha</creator><creator>Kim, Hee Young</creator><general>Springer</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200206</creationdate><title>Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats</title><author>Shin, Joo Hyun ; Fan, Yu ; Kim, Do-Hee ; Jang, Han Byeol ; Chang, Suchan ; Ryu, Yeonhee ; Bae, Jong Han ; Lee, Sanghag ; Lee, Bong Hyo ; Steffensen, Scott C ; Yang, Chae Ha ; Kim, Hee Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-d59489a9aa931caa778f037d63aac6850ee5f75129750d3fb2285a78d48730913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acupuncture</topic><topic>Blood pressure</topic><topic>c-Fos protein</topic><topic>Electrical stimuli</topic><topic>Electroacupuncture</topic><topic>Electrodes</topic><topic>Excitability</topic><topic>Hypertension</topic><topic>Immobilization</topic><topic>Inflammation</topic><topic>Laboratory animals</topic><topic>Mediation</topic><topic>Medulla oblongata</topic><topic>Mesencephalon</topic><topic>Naloxone</topic><topic>Narcotics</topic><topic>Opioids</topic><topic>Original Paper</topic><topic>Printed circuit boards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Joo Hyun</creatorcontrib><creatorcontrib>Fan, Yu</creatorcontrib><creatorcontrib>Kim, Do-Hee</creatorcontrib><creatorcontrib>Jang, Han Byeol</creatorcontrib><creatorcontrib>Chang, Suchan</creatorcontrib><creatorcontrib>Ryu, Yeonhee</creatorcontrib><creatorcontrib>Bae, Jong Han</creatorcontrib><creatorcontrib>Lee, Sanghag</creatorcontrib><creatorcontrib>Lee, Bong Hyo</creatorcontrib><creatorcontrib>Steffensen, Scott C</creatorcontrib><creatorcontrib>Yang, Chae Ha</creatorcontrib><creatorcontrib>Kim, Hee Young</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of physiological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Joo Hyun</au><au>Fan, Yu</au><au>Kim, Do-Hee</au><au>Jang, Han Byeol</au><au>Chang, Suchan</au><au>Ryu, Yeonhee</au><au>Bae, Jong Han</au><au>Lee, Sanghag</au><au>Lee, Bong Hyo</au><au>Steffensen, Scott C</au><au>Yang, Chae Ha</au><au>Kim, Hee Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats</atitle><jtitle>The journal of physiological sciences</jtitle><addtitle>J Physiol Sci</addtitle><date>2020-02-06</date><risdate>2020</risdate><volume>70</volume><issue>1</issue><spage>14</spage><epage>14</epage><pages>14-14</pages><artnum>14</artnum><issn>1880-6546</issn><eissn>1880-6562</eissn><abstract>While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mechanisms remain uncharacterized. 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These findings suggest that mechanical and electrical stimulation at Neuro-Sps suppresses the development of hypertension via mediation of the endogenous opioid system.</abstract><cop>Japan</cop><pub>Springer</pub><pmid>32039692</pmid><doi>10.1186/s12576-020-00735-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acupuncture Blood pressure c-Fos protein Electrical stimuli Electroacupuncture Electrodes Excitability Hypertension Immobilization Inflammation Laboratory animals Mediation Medulla oblongata Mesencephalon Naloxone Narcotics Opioids Original Paper Printed circuit boards |
| title | Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats |
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