Mutation status and burden can improve prognostic prediction of patients with lower‐risk myelodysplastic syndromes

Patients with lower‐risk myelodysplastic syndromes (LR‐MDS) as defined by the International Prognostic Scoring System (IPSS) have more favorable prognosis in general, but significant inter‐individual heterogeneity exists. In this study, we examined the molecular profile of 15 MDS‐relevant genes in 1...

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Veröffentlicht in:	Cancer science 2020-02, Vol.111 (2), p.580-591
Hauptverfasser:	Jiang, Lingxu, Luo, Yingwan, Zhu, Shuanghong, Wang, Lu, Ma, Liya, Zhang, Hua, Shen, Chuying, Yang, Wenli, Ren, Yanling, Zhou, Xinping, Mei, Chen, Ye, Li, Xu, Weilai, Yang, Haiyang, Lu, Chenxi, Jin, Jie, Tong, Hongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aged Aged, 80 and over Bone marrow Data analysis Female Gene Frequency Gene Regulatory Networks Genes Hematology High-Throughput Nucleotide Sequencing - methods Humans Janus kinase 2 lower‐risk myelodysplastic syndromes Male Medical prognosis Middle Aged Mutation mutation burden mutation status Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - genetics Original p53 Protein Population genetics Prognosis Runx1 protein Sequence Analysis, DNA - methods Software Studies Survival Analysis variant allele frequency Young Adult
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