Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

Protein degradation via the use of bivalent chemical degraders provides an alternative strategy to block protein function and assess the biological roles of putative drug targets. This approach capitalizes on the advantages of small-molecule inhibitors while moving beyond the restrictions of traditi...

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Veröffentlicht in:	Cell chemical biology 2020-01, Vol.27 (1), p.47-56.e15
Hauptverfasser:	Potjewyd, Frances, Turner, Anne-Marie W., Beri, Joshua, Rectenwald, Justin M., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Margolis, David M., Pearce, Kenneth H., Herring, Laura E., James, Lindsey I.
Format:	Artikel
Sprache:	eng
Schlagworte:	bivalent chemical degrader Cell Line, Tumor diffuse large B cell lymphoma (DLBCL) embryonic ectoderm development (EED) enhancer of zeste homolog 2 (EZH2) Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology HeLa Cells histone methyltransferase (HMT) Humans Ligands Molecular Structure polycomb repressive complex 2 (PRC2) Polycomb Repressive Complex 2 - metabolism Proteolysis - drug effects Proteolysis-Targeting Chimera (PROTAC) suppressor of zeste homolog 12 (SUZ12) von Hippel-Lindau (VHL)
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