Large-Scale Whole-Genome Sequencing Reveals the Genetic Architecture of Primary Membranoproliferative GN and C3 Glomerulopathy

Primary membranoproliferative GN, including complement 3 (C3) glomerulopathy, is a rare, untreatable kidney disease characterized by glomerular complement deposition. Complement gene mutations can cause familial C3 glomerulopathy, and studies have reported rare variants in complement genes in nonfam...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2020-02, Vol.31 (2), p.365-373
Hauptverfasser:	Levine, Adam P, Chan, Melanie M Y, Sadeghi-Alavijeh, Omid, Wong, Edwin K S, Cook, H Terence, Ashford, Sofie, Carss, Keren, Christian, Martin T, Hall, Matthew, Harris, Claire Louise, McAlinden, Paul, Marchbank, Kevin J, Marks, Stephen D, Maxwell, Heather, Megy, Karyn, Penkett, Christopher J, Mozere, Monika, Stirrups, Kathleen E, Tuna, Salih, Wessels, Julie, Whitehorn, Deborah, Johnson, Sally A, Gale, Daniel P
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Research Complement C3 - immunology Complement C3 Nephritic Factor - analysis Female Glomerulonephritis, Membranoproliferative - etiology Glomerulonephritis, Membranoproliferative - genetics HLA-DQ Antigens - genetics HLA-DR Antigens - genetics Humans Male Serogroup Whole Genome Sequencing
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