Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo
Cisplatin chemotherapy causes myelosuppression and often limits treatment duration and dose escalation in patients. Novel approaches to circumvent or lessen myelotoxicity may improve clinical outcome and quality of life in these patients. Chlorella sorokiniana (CS) is a freshwater unicellular green...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-14 |
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| creator | Perng, Ming-Der Wen, Shu-Fang Pan, I-Horng Chao, Ya-Hsuan Wu, Hsin-Chieh Chang, Chih-Hsuan Lin, Ni-Hsuan Chuang, Kai-An Li, Ming-Han Lin, Shyh-Horng Lin, Chi-Chen |
| description | Cisplatin chemotherapy causes myelosuppression and often limits treatment duration and dose escalation in patients. Novel approaches to circumvent or lessen myelotoxicity may improve clinical outcome and quality of life in these patients. Chlorella sorokiniana (CS) is a freshwater unicellular green alga and exhibits encouraging efficacy in immunomodulation and anticancer in preclinical studies. However, the efficacy of CS on chemoprotection remains unclear. We report here, for the first time, that CS extract (CSE) could protect normal myeloid cells and PBMCs from cisplatin toxicity. Also, cisplatin-induced apoptosis in HL-60 cells was rescued through reservation of mitochondrial function, inhibition of cytochrome c release to cytosol, and suppression of caspase and PARP activation. Intriguingly, cotreatment of CSE attenuated cisplatin-evoked hypocellularity of bone marrow in mice. Furthermore, we observed the enhancement of CSF-GM activity in bone marrow and spleen in mice administered CSE and cisplatin, along with increased CD11b levels in spleen. In conclusion, we uncovered a novel mechanism of CSE on myeloprotection, whereby potentially supports the use of CSE as a chemoprotector against cisplatin-induced bone marrow toxicity. Further clinical investigation of CSE in combination with cisplatin is warranted. |
| doi_str_mv | 10.1155/2020/7353618 |
| format | Article |
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Novel approaches to circumvent or lessen myelotoxicity may improve clinical outcome and quality of life in these patients. Chlorella sorokiniana (CS) is a freshwater unicellular green alga and exhibits encouraging efficacy in immunomodulation and anticancer in preclinical studies. However, the efficacy of CS on chemoprotection remains unclear. We report here, for the first time, that CS extract (CSE) could protect normal myeloid cells and PBMCs from cisplatin toxicity. Also, cisplatin-induced apoptosis in HL-60 cells was rescued through reservation of mitochondrial function, inhibition of cytochrome c release to cytosol, and suppression of caspase and PARP activation. Intriguingly, cotreatment of CSE attenuated cisplatin-evoked hypocellularity of bone marrow in mice. Furthermore, we observed the enhancement of CSF-GM activity in bone marrow and spleen in mice administered CSE and cisplatin, along with increased CD11b levels in spleen. In conclusion, we uncovered a novel mechanism of CSE on myeloprotection, whereby potentially supports the use of CSE as a chemoprotector against cisplatin-induced bone marrow toxicity. Further clinical investigation of CSE in combination with cisplatin is warranted.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2020/7353618</identifier><identifier>PMID: 32047579</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Apoptosis ; Bone marrow ; Cancer ; Cancer therapies ; Chemotherapy ; Cisplatin ; Cytochrome ; Cytochrome c ; Deoxyribonucleic acid ; DNA ; Ethylenediaminetetraacetic acid ; Leukemia ; Lung cancer ; Mitochondria ; Penicillin ; Prevention ; Scientific equipment and supplies industry ; Tumors</subject><ispartof>Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-14</ispartof><rights>Copyright © 2020 Shyh-Horng Lin et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Shyh-Horng Lin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Shyh-Horng Lin et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-a25dd2e48fad74fac6707bde0fd5084c1f9366db04acfd0fc0b59170f13830973</citedby><cites>FETCH-LOGICAL-c499t-a25dd2e48fad74fac6707bde0fd5084c1f9366db04acfd0fc0b59170f13830973</cites><orcidid>0000-0002-1464-0231 ; 0000-0002-2000-4127 ; 0000-0001-5290-9265 ; 0000-0002-1884-3714 ; 0000-0003-4524-3615 ; 0000-0001-8283-6589 ; 0000-0001-9066-553X ; 0000-0002-1827-6940 ; 0000-0002-0870-4198 ; 0000-0002-9959-6224</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003270/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003270/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32047579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>McCarthy, Antonio Desmond</contributor><contributor>Antonio Desmond McCarthy</contributor><creatorcontrib>Perng, Ming-Der</creatorcontrib><creatorcontrib>Wen, Shu-Fang</creatorcontrib><creatorcontrib>Pan, I-Horng</creatorcontrib><creatorcontrib>Chao, Ya-Hsuan</creatorcontrib><creatorcontrib>Wu, Hsin-Chieh</creatorcontrib><creatorcontrib>Chang, Chih-Hsuan</creatorcontrib><creatorcontrib>Lin, Ni-Hsuan</creatorcontrib><creatorcontrib>Chuang, Kai-An</creatorcontrib><creatorcontrib>Li, Ming-Han</creatorcontrib><creatorcontrib>Lin, Shyh-Horng</creatorcontrib><creatorcontrib>Lin, Chi-Chen</creatorcontrib><title>Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Cisplatin chemotherapy causes myelosuppression and often limits treatment duration and dose escalation in patients. Novel approaches to circumvent or lessen myelotoxicity may improve clinical outcome and quality of life in these patients. Chlorella sorokiniana (CS) is a freshwater unicellular green alga and exhibits encouraging efficacy in immunomodulation and anticancer in preclinical studies. However, the efficacy of CS on chemoprotection remains unclear. We report here, for the first time, that CS extract (CSE) could protect normal myeloid cells and PBMCs from cisplatin toxicity. Also, cisplatin-induced apoptosis in HL-60 cells was rescued through reservation of mitochondrial function, inhibition of cytochrome c release to cytosol, and suppression of caspase and PARP activation. Intriguingly, cotreatment of CSE attenuated cisplatin-evoked hypocellularity of bone marrow in mice. Furthermore, we observed the enhancement of CSF-GM activity in bone marrow and spleen in mice administered CSE and cisplatin, along with increased CD11b levels in spleen. In conclusion, we uncovered a novel mechanism of CSE on myeloprotection, whereby potentially supports the use of CSE as a chemoprotector against cisplatin-induced bone marrow toxicity. Further clinical investigation of CSE in combination with cisplatin is warranted.</description><subject>Apoptosis</subject><subject>Bone marrow</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Cytochrome</subject><subject>Cytochrome c</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Leukemia</subject><subject>Lung cancer</subject><subject>Mitochondria</subject><subject>Penicillin</subject><subject>Prevention</subject><subject>Scientific equipment and supplies industry</subject><subject>Tumors</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUtvEzEURi1ERUthxxqNxKYSDL1-zHi8QaqiApGKYAFsWFiOH43LxA62J23-PTNKSAsrVrblo6P73Q-hFxjeYtw05wQInHPa0BZ3j9AJFozUIAR7fLgDHKOnOd8AtJQw_AQdUwKMN1ycoB-zZR-T7XtV5ZjiTx-8Cqq6vCtJ6VJ9SXZjQ8nVzOd1r4oP9TyYQVtTfdraPpZ457Uv22oequ--pFipYHaPTXyGjpzqs32-P0_Rt_eXX2cf66vPH-azi6taMyFKrUhjDLGsc8pw5pRuOfCFseBMAx3T2AnatmYBTGlnwGlYNAJzcJh2FASnp-jdzrseFitr9DhwUr1cJ79SaSuj8vLvn-CX8jpuJAeghMMoONsLUvw12Fzkymc9LSXYOGRJaMNwS6DBI_rqH_QmDimM8SYKAHPykLpWvZU-uDitc5LKi5YQ2gpou5F6s6N0ijkn6w4jY5BTt3LqVu67HfGXD2Me4D9ljsDrHbD0wahb_586OzLWqXt6DEoZp78B-N61cw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Perng, Ming-Der</creator><creator>Wen, Shu-Fang</creator><creator>Pan, I-Horng</creator><creator>Chao, Ya-Hsuan</creator><creator>Wu, Hsin-Chieh</creator><creator>Chang, Chih-Hsuan</creator><creator>Lin, Ni-Hsuan</creator><creator>Chuang, Kai-An</creator><creator>Li, Ming-Han</creator><creator>Lin, Shyh-Horng</creator><creator>Lin, Chi-Chen</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1464-0231</orcidid><orcidid>https://orcid.org/0000-0002-2000-4127</orcidid><orcidid>https://orcid.org/0000-0001-5290-9265</orcidid><orcidid>https://orcid.org/0000-0002-1884-3714</orcidid><orcidid>https://orcid.org/0000-0003-4524-3615</orcidid><orcidid>https://orcid.org/0000-0001-8283-6589</orcidid><orcidid>https://orcid.org/0000-0001-9066-553X</orcidid><orcidid>https://orcid.org/0000-0002-1827-6940</orcidid><orcidid>https://orcid.org/0000-0002-0870-4198</orcidid><orcidid>https://orcid.org/0000-0002-9959-6224</orcidid></search><sort><creationdate>2020</creationdate><title>Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo</title><author>Perng, Ming-Der ; Wen, Shu-Fang ; Pan, I-Horng ; Chao, Ya-Hsuan ; Wu, Hsin-Chieh ; Chang, Chih-Hsuan ; Lin, Ni-Hsuan ; Chuang, Kai-An ; Li, Ming-Han ; Lin, Shyh-Horng ; Lin, Chi-Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-a25dd2e48fad74fac6707bde0fd5084c1f9366db04acfd0fc0b59170f13830973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>Bone marrow</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Cytochrome</topic><topic>Cytochrome c</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Leukemia</topic><topic>Lung cancer</topic><topic>Mitochondria</topic><topic>Penicillin</topic><topic>Prevention</topic><topic>Scientific equipment and supplies industry</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perng, Ming-Der</creatorcontrib><creatorcontrib>Wen, Shu-Fang</creatorcontrib><creatorcontrib>Pan, I-Horng</creatorcontrib><creatorcontrib>Chao, Ya-Hsuan</creatorcontrib><creatorcontrib>Wu, Hsin-Chieh</creatorcontrib><creatorcontrib>Chang, Chih-Hsuan</creatorcontrib><creatorcontrib>Lin, Ni-Hsuan</creatorcontrib><creatorcontrib>Chuang, Kai-An</creatorcontrib><creatorcontrib>Li, Ming-Han</creatorcontrib><creatorcontrib>Lin, Shyh-Horng</creatorcontrib><creatorcontrib>Lin, Chi-Chen</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perng, Ming-Der</au><au>Wen, Shu-Fang</au><au>Pan, I-Horng</au><au>Chao, Ya-Hsuan</au><au>Wu, Hsin-Chieh</au><au>Chang, Chih-Hsuan</au><au>Lin, Ni-Hsuan</au><au>Chuang, Kai-An</au><au>Li, Ming-Han</au><au>Lin, Shyh-Horng</au><au>Lin, Chi-Chen</au><au>McCarthy, Antonio Desmond</au><au>Antonio Desmond McCarthy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Cisplatin chemotherapy causes myelosuppression and often limits treatment duration and dose escalation in patients. Novel approaches to circumvent or lessen myelotoxicity may improve clinical outcome and quality of life in these patients. Chlorella sorokiniana (CS) is a freshwater unicellular green alga and exhibits encouraging efficacy in immunomodulation and anticancer in preclinical studies. However, the efficacy of CS on chemoprotection remains unclear. We report here, for the first time, that CS extract (CSE) could protect normal myeloid cells and PBMCs from cisplatin toxicity. Also, cisplatin-induced apoptosis in HL-60 cells was rescued through reservation of mitochondrial function, inhibition of cytochrome c release to cytosol, and suppression of caspase and PARP activation. Intriguingly, cotreatment of CSE attenuated cisplatin-evoked hypocellularity of bone marrow in mice. Furthermore, we observed the enhancement of CSF-GM activity in bone marrow and spleen in mice administered CSE and cisplatin, along with increased CD11b levels in spleen. In conclusion, we uncovered a novel mechanism of CSE on myeloprotection, whereby potentially supports the use of CSE as a chemoprotector against cisplatin-induced bone marrow toxicity. 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| source | Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Apoptosis Bone marrow Cancer Cancer therapies Chemotherapy Cisplatin Cytochrome Cytochrome c Deoxyribonucleic acid DNA Ethylenediaminetetraacetic acid Leukemia Lung cancer Mitochondria Penicillin Prevention Scientific equipment and supplies industry Tumors |
| title | Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo |
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