Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA -Mutant Colorectal Cancer

Activation of the epithelial-to-mesenchymal transition (EMT) program is a critical mechanism for initiating cancer progression and migration. Colorectal cancers contain many genetic and epigenetic alterations that can contribute to EMT. Mutations activating the PI3K/AKT signaling pathway are observe...

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Veröffentlicht in:	Molecular cancer research 2020-02, Vol.18 (2), p.264-277
Hauptverfasser:	Miller, Samuel A, Policastro, Robert A, Savant, Sudha S, Sriramkumar, Shruthi, Ding, Ning, Lu, Xiaoyu, Mohammad, Helai P, Cao, Sha, Kalin, Jay H, Cole, Philip A, Zentner, Gabriel E, O'Hagan, Heather M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Chromatin - genetics Chromatin - metabolism Class I Phosphatidylinositol 3-Kinases - genetics Class I Phosphatidylinositol 3-Kinases - metabolism Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Epithelial-Mesenchymal Transition - genetics Gene Knockout Techniques HCT116 Cells Histone Demethylases - genetics Histone Demethylases - metabolism HT29 Cells Humans Mutation Phosphorylation Protein Stability Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Transfection
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