Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria

Colibactins are genotoxic secondary metabolites produced in select Enterobacteriaceae, which induce downstream DNA double-strand breaks (DSBs) in human cell lines and are thought to promote the formation of colorectal tumors. Although key structural and functional features of colibactins have been e...

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Veröffentlicht in:	ACS chemical biology 2018-12, Vol.13 (12), p.3286-3293
Hauptverfasser:	Shine, Emilee E, Xue, Mengzhao, Patel, Jaymin R, Healy, Alan R, Surovtseva, Yulia V, Herzon, Seth B, Crawford, Jason M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation - drug effects Cell Line, Tumor Cross-Linking Reagents - pharmacology DNA - chemistry DNA - genetics DNA Breaks, Double-Stranded - drug effects Escherichia coli - genetics Humans Mutagens - pharmacology Peptides - genetics Peptides - pharmacology Polyketides - pharmacology
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