Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication

The lipid kinase PI4KB, which generates phosphatidylinositol 4‐phosphate (PI4P), is a key enzyme in regulating membrane transport and is also hijacked by multiple picornaviruses to mediate viral replication. PI4KB can interact with multiple protein binding partners, which are differentially manipula...

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Veröffentlicht in:	EMBO reports 2020-02, Vol.21 (2), p.e48441-n/a
Hauptverfasser:	McPhail, Jacob A, Lyoo, Heyrhyoung, Pemberton, Joshua G, Hoffmann, Reece M, van Elst, Wendy, Strating, Jeroen RPM, Jenkins, Meredith L, Stariha, Jordan TB, Powell, Cameron J, Boulanger, Martin J, Balla, Tamas, van Kuppeveld, Frank JM, Burke, John E
Format:	Artikel
Sprache:	eng
Schlagworte:	Active control Animals Binding c10orf76 Deuterium Disruption EMBO20 Enterovirus - genetics Enterovirus - metabolism Enteroviruses GBF1 Golgi apparatus Golgi Apparatus - metabolism HDX‐MS Kinases Lipid kinase Lipids Mass spectrometry Mass spectroscopy Membranes Mutation Organelles Phosphatidylinositol Phosphates Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism PI4KB Protein Binding Protein kinase A Proteins Recruitment Replication Sf9 Cells viral replication Virus Replication
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