Nitric oxide, asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in psychotic exacerbation of schizophrenia and bipolar disorder manic episode
To examine the changes in nitric oxide (NO), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in schizophrenia during acute psychotic exacerbation and in bipolar disorder during mania and to compare those changes to healthy controls. Thirty schizophrenia p...
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| Veröffentlicht in: | Saudi medical journal 2020-01, Vol.41 (1), p.38-45 |
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| creator | Ustundag, Mehmet F Ozcan, Halil Gencer, Ali G Yilmaz, Enver D Uğur, Kerim Oral, Elif Bilici, Mustafa |
| description | To examine the changes in nitric oxide (NO), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in schizophrenia during acute psychotic exacerbation and in bipolar disorder during mania and to compare those changes to healthy controls.
Thirty schizophrenia patients with acute psychotic exacerbation and 30 bipolar disorder patients with mania, who attended the Psychiatry Department, Erenköy Hospital for Mental and Nervous Diseases, Istanbul, Turkey, in 2010. Thirty healthy controls were included. The diagnosis was made using the Structured Clinical Interview for Axis I Disorders (SCID-I) interviews. Patients' demographic data were recorded, and NO, SDMA, L-arginine, and ADMA levels were studied.
Nitric oxide levels in schizophrenia patients were significantly lower than the control group. Nitric oxide levels in the bipolar group were lower than the control group but the difference was not statistically significant. The levels of SDMA, ADMA, and L-arginine were found to be significantly higher in schizophrenia and bipolar disorder patients than the control group. The disease duration was slightly negatively correlated with NO levels in bipolar patients. In schizophrenia patients, the disease severity was slightly positively correlated with NO levels.
Significant changes in NO, SDMA, ADMA, and L-arginine levels in schizophrenia and bipolar disorder patients suggest that NO and inhibitors of NO might be implicated in the neurobiology of schizophrenia and bipolar disorder. |
| doi_str_mv | 10.15537/smj.2020.1.24817 |
| format | Article |
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Thirty schizophrenia patients with acute psychotic exacerbation and 30 bipolar disorder patients with mania, who attended the Psychiatry Department, Erenköy Hospital for Mental and Nervous Diseases, Istanbul, Turkey, in 2010. Thirty healthy controls were included. The diagnosis was made using the Structured Clinical Interview for Axis I Disorders (SCID-I) interviews. Patients' demographic data were recorded, and NO, SDMA, L-arginine, and ADMA levels were studied.
Nitric oxide levels in schizophrenia patients were significantly lower than the control group. Nitric oxide levels in the bipolar group were lower than the control group but the difference was not statistically significant. The levels of SDMA, ADMA, and L-arginine were found to be significantly higher in schizophrenia and bipolar disorder patients than the control group. The disease duration was slightly negatively correlated with NO levels in bipolar patients. In schizophrenia patients, the disease severity was slightly positively correlated with NO levels.
Significant changes in NO, SDMA, ADMA, and L-arginine levels in schizophrenia and bipolar disorder patients suggest that NO and inhibitors of NO might be implicated in the neurobiology of schizophrenia and bipolar disorder.</description><identifier>ISSN: 0379-5284</identifier><identifier>EISSN: 1658-3175</identifier><identifier>DOI: 10.15537/smj.2020.1.24817</identifier><identifier>PMID: 31915793</identifier><language>eng</language><publisher>Saudi Arabia: Saudi Medical Journal</publisher><subject>Amino acids ; Arginine ; Arginine - analogs & derivatives ; Arginine - metabolism ; Biochemistry ; Bipolar disorder ; Bipolar Disorder - metabolism ; Chemicals ; Diagnosis ; Disease Progression ; Diseases ; Humans ; Mania ; Neurophysiology ; Nitric oxide ; Nitric Oxide - metabolism ; Nitrogen oxides ; Original ; Oxidative stress ; Schizophrenia ; Schizophrenia - metabolism</subject><ispartof>Saudi medical journal, 2020-01, Vol.41 (1), p.38-45</ispartof><rights>COPYRIGHT 2020 Saudi Medical Journal</rights><rights>Saudi Medical Journal 2020. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © Saudi Medical Journal 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-c8c5e6941735190c4480a0e9d7bfebffa080b2479304c7c6787e15eb1024cb33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001079/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001079/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31915793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ustundag, Mehmet F</creatorcontrib><creatorcontrib>Ozcan, Halil</creatorcontrib><creatorcontrib>Gencer, Ali G</creatorcontrib><creatorcontrib>Yilmaz, Enver D</creatorcontrib><creatorcontrib>Uğur, Kerim</creatorcontrib><creatorcontrib>Oral, Elif</creatorcontrib><creatorcontrib>Bilici, Mustafa</creatorcontrib><title>Nitric oxide, asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in psychotic exacerbation of schizophrenia and bipolar disorder manic episode</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>To examine the changes in nitric oxide (NO), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in schizophrenia during acute psychotic exacerbation and in bipolar disorder during mania and to compare those changes to healthy controls.
Thirty schizophrenia patients with acute psychotic exacerbation and 30 bipolar disorder patients with mania, who attended the Psychiatry Department, Erenköy Hospital for Mental and Nervous Diseases, Istanbul, Turkey, in 2010. Thirty healthy controls were included. The diagnosis was made using the Structured Clinical Interview for Axis I Disorders (SCID-I) interviews. Patients' demographic data were recorded, and NO, SDMA, L-arginine, and ADMA levels were studied.
Nitric oxide levels in schizophrenia patients were significantly lower than the control group. Nitric oxide levels in the bipolar group were lower than the control group but the difference was not statistically significant. The levels of SDMA, ADMA, and L-arginine were found to be significantly higher in schizophrenia and bipolar disorder patients than the control group. The disease duration was slightly negatively correlated with NO levels in bipolar patients. In schizophrenia patients, the disease severity was slightly positively correlated with NO levels.
Significant changes in NO, SDMA, ADMA, and L-arginine levels in schizophrenia and bipolar disorder patients suggest that NO and inhibitors of NO might be implicated in the neurobiology of schizophrenia and bipolar disorder.</description><subject>Amino acids</subject><subject>Arginine</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - metabolism</subject><subject>Biochemistry</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - metabolism</subject><subject>Chemicals</subject><subject>Diagnosis</subject><subject>Disease Progression</subject><subject>Diseases</subject><subject>Humans</subject><subject>Mania</subject><subject>Neurophysiology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitrogen oxides</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Schizophrenia</subject><subject>Schizophrenia - metabolism</subject><issn>0379-5284</issn><issn>1658-3175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1ks9u1DAQxi0EosvCA3BBkbiSZRzbcXJBqipakFZw6d1ynMnGq8QOdrbq9o14S9y0LFQC-TCeP99PM9JHyFsKGyoEkx_juN8UUKR0U_CKymdkRUtR5YxK8ZysgMk6F0XFz8irGPcArCyhfEnOGK2pkDVbkZ_f7BysyfytbfFDpuNxHHGptDZ9-uOgw84661Lz_71Muzbb5qd0wBscYmZdNsWj6f2cNHirDYZGz9a7zHdZNL2981Mf0Fm9ABo7-YRM9OhDiyEbtbsXTilv8TV50ekh4pvHuCbXl5-vL77k2-9XXy_Ot7nhgs65qYzAsuZUMkFrMJxXoAHrVjYdNl2noYKm4Ol44EaaUlYSqcCGQsFNw9iafHrATodmxNagm4Me1BTsqMNReW3V046zvdr5GyUBKCTsmrx_BAT_44BxVnt_CC6trApWioLVwOHP1E4PqKzrfIKZ0UajzkuaVodymdr8Yyq9FkdrvMPOpvoTAX0QmOBjDNidFqegFs-o5Bl17xlF1eKZpHn398UnxW-TsF9ODcG2</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Ustundag, Mehmet F</creator><creator>Ozcan, Halil</creator><creator>Gencer, Ali G</creator><creator>Yilmaz, Enver D</creator><creator>Uğur, Kerim</creator><creator>Oral, Elif</creator><creator>Bilici, Mustafa</creator><general>Saudi Medical Journal</general><general>Prince Sultan Military Medical City (PSMMC)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>202001</creationdate><title>Nitric oxide, asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in psychotic exacerbation of schizophrenia and bipolar disorder manic episode</title><author>Ustundag, Mehmet F ; Ozcan, Halil ; Gencer, Ali G ; Yilmaz, Enver D ; Uğur, Kerim ; Oral, Elif ; Bilici, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-c8c5e6941735190c4480a0e9d7bfebffa080b2479304c7c6787e15eb1024cb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acids</topic><topic>Arginine</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - metabolism</topic><topic>Biochemistry</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - metabolism</topic><topic>Chemicals</topic><topic>Diagnosis</topic><topic>Disease Progression</topic><topic>Diseases</topic><topic>Humans</topic><topic>Mania</topic><topic>Neurophysiology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitrogen oxides</topic><topic>Original</topic><topic>Oxidative stress</topic><topic>Schizophrenia</topic><topic>Schizophrenia - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ustundag, Mehmet F</creatorcontrib><creatorcontrib>Ozcan, Halil</creatorcontrib><creatorcontrib>Gencer, Ali G</creatorcontrib><creatorcontrib>Yilmaz, Enver D</creatorcontrib><creatorcontrib>Uğur, Kerim</creatorcontrib><creatorcontrib>Oral, Elif</creatorcontrib><creatorcontrib>Bilici, Mustafa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ustundag, Mehmet F</au><au>Ozcan, Halil</au><au>Gencer, Ali G</au><au>Yilmaz, Enver D</au><au>Uğur, Kerim</au><au>Oral, Elif</au><au>Bilici, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide, asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in psychotic exacerbation of schizophrenia and bipolar disorder manic episode</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2020-01</date><risdate>2020</risdate><volume>41</volume><issue>1</issue><spage>38</spage><epage>45</epage><pages>38-45</pages><issn>0379-5284</issn><eissn>1658-3175</eissn><abstract>To examine the changes in nitric oxide (NO), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in schizophrenia during acute psychotic exacerbation and in bipolar disorder during mania and to compare those changes to healthy controls.
Thirty schizophrenia patients with acute psychotic exacerbation and 30 bipolar disorder patients with mania, who attended the Psychiatry Department, Erenköy Hospital for Mental and Nervous Diseases, Istanbul, Turkey, in 2010. Thirty healthy controls were included. The diagnosis was made using the Structured Clinical Interview for Axis I Disorders (SCID-I) interviews. Patients' demographic data were recorded, and NO, SDMA, L-arginine, and ADMA levels were studied.
Nitric oxide levels in schizophrenia patients were significantly lower than the control group. Nitric oxide levels in the bipolar group were lower than the control group but the difference was not statistically significant. The levels of SDMA, ADMA, and L-arginine were found to be significantly higher in schizophrenia and bipolar disorder patients than the control group. The disease duration was slightly negatively correlated with NO levels in bipolar patients. In schizophrenia patients, the disease severity was slightly positively correlated with NO levels.
Significant changes in NO, SDMA, ADMA, and L-arginine levels in schizophrenia and bipolar disorder patients suggest that NO and inhibitors of NO might be implicated in the neurobiology of schizophrenia and bipolar disorder.</abstract><cop>Saudi Arabia</cop><pub>Saudi Medical Journal</pub><pmid>31915793</pmid><doi>10.15537/smj.2020.1.24817</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Arginine Arginine - analogs & derivatives Arginine - metabolism Biochemistry Bipolar disorder Bipolar Disorder - metabolism Chemicals Diagnosis Disease Progression Diseases Humans Mania Neurophysiology Nitric oxide Nitric Oxide - metabolism Nitrogen oxides Original Oxidative stress Schizophrenia Schizophrenia - metabolism |
| title | Nitric oxide, asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in psychotic exacerbation of schizophrenia and bipolar disorder manic episode |
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