MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury

The granulocyte-specific microRNA-223 (miR-223) has recently emerged as a negative regulator of NOD-like receptor 3 (NLRP3) expression, a central key player in chronic hepatic injuries such as fibrotic nonalcoholic steatohepatitis (NASH), as well as in other liver conditions including acute hepatiti...

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Veröffentlicht in:	Molecular therapy 2020-02, Vol.28 (2), p.653-663
Hauptverfasser:	Jimenez Calvente, Carolina, Del Pilar, Hana, Tameda, Masahiko, Johnson, Casey D., Feldstein, Ariel E.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute and chronic liver injury Animals Biomarkers Disease Models, Animal Female Humans IL-1β Immunohistochemistry inflammasome Inflammasomes - metabolism Lipopolysaccharides - adverse effects Liver Diseases - etiology Liver Diseases - metabolism Liver Diseases - pathology liver fibrosis macrophage Macrophages - immunology Macrophages - metabolism Mice microRNA MicroRNAs - genetics monocyte Monocytes - immunology Monocytes - metabolism Monocytes - pathology NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Original RNA Interference
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