The role of HOPX in normal tissues and tumor progression
The homeodomain-only protein homeobox (HOPX) as the smallest homeodomain protein, lacks certain conserved residues required for DNA binding. Through our literature search, we reviewed the current understandings of HOPX in normal tissues and tumor progression. HOPX was initially identified as a criti...
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| creator | Liu, Yijun Zhang, Wenling |
| description | The homeodomain-only protein homeobox (HOPX) as the smallest homeodomain protein, lacks certain conserved residues required for DNA binding. Through our literature search, we reviewed the current understandings of HOPX in normal tissues and tumor progression. HOPX was initially identified as a critical transcription factor in various normal tissues, which interacted with serum response factor (SRF) or other substance to regulate normal physiological function. However, HOPX is at a low expression or methylation level in tumors. These data indicated that HOPX may play a very important role in regulating differentiation phenotype and tumor suppressive function. We predicted the prognosis of HOPX in tumors from TCGA database and discussed the downstream genes of HOPX. To understand how HOPX is involved in the mechanisms between physical and pathological conditions could lead to novel therapeutic strategies for treatment. |
| doi_str_mv | 10.1042/BSR20191953 |
| format | Article |
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To understand how HOPX is involved in the mechanisms between physical and pathological conditions could lead to novel therapeutic strategies for treatment.</description><subject>Animals</subject><subject>Cancer</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Migration, Adhesion & Morphology</subject><subject>Diagnostics & Biomarkers</subject><subject>Disease Progression</subject><subject>DNA Methylation - physiology</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Humans</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Review</subject><subject>Serum Response Factor - metabolism</subject><subject>Tumor Suppressor Proteins - metabolism</subject><issn>0144-8463</issn><issn>1573-4935</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1LAzEUxIMotlZP3iVHQVbztZvNRdDiFxQq2oO3kGxf2pXdTU12Bf97t7SWeprD_Jh5bxA6p-SaEsFu7t_fGKGKqpQfoCFNJU-E4ukhGhIqRJKLjA_QSYyfhJDeEMdowGmvktEhymdLwMFXgL3Dz9PXD1w2uPGhNhVuyxg7iNg0c9x2tQ94FfwiQIylb07RkTNVhLOtjtDs8WE2fk4m06eX8d0kKYSQbcIUo1IV3EFmU-YsBU6sUllK5ww4WK4ss5RxowolpcqtKhyHzIFQxOaSj9DtJnbV2RrmBTRtMJVehbI24Ud7U-r_TlMu9cJ_60wpSck64HIbEPxX_02r6zIWUFWmAd9FzTjPSZoLtkavNmgRfIwB3K6GEr2eWu9N3dMX-5ft2L9t-S_-xHkE</recordid><startdate>20200131</startdate><enddate>20200131</enddate><creator>Liu, Yijun</creator><creator>Zhang, Wenling</creator><general>Portland Press Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1586-6363</orcidid><orcidid>https://orcid.org/0000-0002-1170-0470</orcidid></search><sort><creationdate>20200131</creationdate><title>The role of HOPX in normal tissues and tumor progression</title><author>Liu, Yijun ; Zhang, Wenling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-292179c3fe6b52fb1e30b99651d2e3eb39b2b123a9c97798b9cf3e6fe490b873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Cancer</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Migration, Adhesion & Morphology</topic><topic>Diagnostics & Biomarkers</topic><topic>Disease Progression</topic><topic>DNA Methylation - physiology</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Humans</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Review</topic><topic>Serum Response Factor - metabolism</topic><topic>Tumor Suppressor Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yijun</creatorcontrib><creatorcontrib>Zhang, Wenling</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioscience reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yijun</au><au>Zhang, Wenling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of HOPX in normal tissues and tumor progression</atitle><jtitle>Bioscience reports</jtitle><addtitle>Biosci Rep</addtitle><date>2020-01-31</date><risdate>2020</risdate><volume>40</volume><issue>1</issue><issn>0144-8463</issn><eissn>1573-4935</eissn><abstract>The homeodomain-only protein homeobox (HOPX) as the smallest homeodomain protein, lacks certain conserved residues required for DNA binding. 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| source | MEDLINE; PubMed Central (Training); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cancer Cell Differentiation - physiology Cell Migration, Adhesion & Morphology Diagnostics & Biomarkers Disease Progression DNA Methylation - physiology Homeodomain Proteins - metabolism Humans Neoplasms - metabolism Neoplasms - pathology Review Serum Response Factor - metabolism Tumor Suppressor Proteins - metabolism |
| title | The role of HOPX in normal tissues and tumor progression |
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