Compromised steady‐state germinal center activity with age in nonhuman primates

Age‐related reductions in vaccine‐induced B cells in aging indicate that germinal centers (GCs), the anatomical site where the development of humoral responses takes place, may lose efficacy with age. We have investigated the baseline follicular and GC composition in nonhuman primates (NHPs) with re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Aging cell 2020-02, Vol.19 (2), p.e13087-n/a
Hauptverfasser:	Shankwitz, Kimberly, Pallikkuth, Suresh, Sirupangi, Tirupataiah, Kirk Kvistad, Daniel, Russel, Kyle Blaine, Pahwa, Rajendra, Gama, Lucio, Koup, Richard A., Pan, Li, Villinger, Francois, Pahwa, Savita, Petrovas, Constantinos
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - immunology Animals Antigens Antigens, CD - metabolism B cells B-Lymphocytes - immunology CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Flow cytometry Follicles Forkhead Transcription Factors - metabolism Germinal Center - cytology Germinal Center - immunology Germinal Center - pathology Germinal centers Granulocytes - metabolism Immune system Immunity, Humoral Inflammation - immunology Inflammation - metabolism Inflammation - physiopathology Leukocytes (granulocytic) Listeria Lymph Nodes - cytology Lymph Nodes - immunology Lymph Nodes - physiopathology Lymphocyte Activation Gene 3 Protein Lymphocytes Lymphocytes B Lymphocytes T Macaca mulatta Monocytes Monocytes - metabolism Multiple regression analysis Nanoparticles Older people Original Paper Original Papers T cells Tfh cells Vaccines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!