A synthetic lethal drug combination mimics glucose deprivation–induced cancer cell death in the presence of glucose

Metabolic reprogramming in cancer cells can increase their dependence on metabolic substrates such as glucose. As such, the vulnerability of cancer cells to glucose deprivation creates an attractive opportunity for therapeutic intervention. Because it is not possible to starve tumors of glucose in v...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2020-01, Vol.295 (5), p.1350-1365
Hauptverfasser:	Joly, James H., Delfarah, Alireza, Phung, Philip S., Parrish, Sydney, Graham, Nicholas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!